Genetic recombination is targeted towards gene promoter regions in dogs

Auton, Adam, Li, Ying Rui, Kidd, Jeffrey, Oliveira, Kyle, Nadel, Julie, Holloway, J. Kim, Hayward, Jessica J., Cohen, Paula E., Greally, John M., Wang, Jun, Bustamante, Carlos D. and Boyko, Adam R. (2013) Genetic recombination is targeted towards gene promoter regions in dogs. PLoS Genetics, 9 12: 1-9. doi:10.1371/journal.pgen.1003984

Author Auton, Adam
Li, Ying Rui
Kidd, Jeffrey
Oliveira, Kyle
Nadel, Julie
Holloway, J. Kim
Hayward, Jessica J.
Cohen, Paula E.
Greally, John M.
Wang, Jun
Bustamante, Carlos D.
Boyko, Adam R.
Title Genetic recombination is targeted towards gene promoter regions in dogs
Journal name PLoS Genetics   Check publisher's open access policy
ISSN 1553-7390
Publication date 2013-12-12
Year available 2013
Sub-type Article (original research)
DOI 10.1371/journal.pgen.1003984
Open Access Status DOI
Volume 9
Issue 12
Start page 1
End page 9
Total pages 9
Place of publication San Francisco, CA, United States
Publisher Public Library of Science
Language eng
Formatted abstract
The identification of the H3K4 trimethylase, PRDM9, as the gene responsible for recombination hotspot localization has provided considerable insight into the mechanisms by which recombination is initiated in mammals. However, uniquely amongst mammals, canids appear to lack a functional version of PRDM9 and may therefore provide a model for understanding recombination that occurs in the absence of PRDM9, and thus how PRDM9 functions to shape the recombination landscape. We have constructed a fine-scale genetic map from patterns of linkage disequilibrium assessed using high-throughput sequence data from 51 free-ranging dogs, Canis lupus familiaris. While broad-scale properties of recombination appear similar to other mammalian species, our fine-scale estimates indicate that canine highly elevated recombination rates are observed in the vicinity of CpG rich regions including gene promoter regions, but show little association with H3K4 trimethylation marks identified in spermatocytes. By comparison to genomic data from the Andean fox, Lycalopex culpaeus, we show that biased gene conversion is a plausible mechanism by which the high CpG content of the dog genome could have occurred.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Institute for Molecular Bioscience - Publications
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Created: Fri, 04 Sep 2015, 01:00:10 EST by Mr Mathew Carter on behalf of Institute for Molecular Bioscience