The oral and gut microbiomes are perturbed in rheumatoid arthritis and partly normalized after treatment

Zhang, Xuan, Zhang, Dongya, Jia, Huijue, Feng, Qiang, Wang, Donghui, Liang, Di, Wu, Xiangni, Li, Junhua, Tang, Longqing, Li, Yin, Lan, Zhou, Chen, Bing, Li, Yanli, Zhong, Huanzi, Xie, Hailiang, Jie, Zhuye, Chen, Weineng, Tang, Shanmei, Xu, Xiaoqiang, Wang, Xiaokai, Cai, Xianghang, Liu, Sheng, Xia, Yan, Li, Jiyang, Qiao, Xingye, Al-Aama, Jumana Yousuf, Chen, Hua, Wang, Li, Wu, Qing-jun, Zhang, Fengchun, Zheng, Wenjie, Li, Yongzhe, Zhang, Mingrong, Luo, Guangwen, Xue, Wenbin, Xiao, Liang, Li, Jun, Chen, Wanting, Xu, Xun, Yin, Ye, Yang, Huanming, Wang, Jian, Kristiansen, Karsten, Liu, Liang, Li, Ting, Huang, Qingchun, Li, Yingrui and Wang, Jun (2015) The oral and gut microbiomes are perturbed in rheumatoid arthritis and partly normalized after treatment. Nature Medicine, 21 8: 895-905. doi:10.1038/nm.3914

Author Zhang, Xuan
Zhang, Dongya
Jia, Huijue
Feng, Qiang
Wang, Donghui
Liang, Di
Wu, Xiangni
Li, Junhua
Tang, Longqing
Li, Yin
Lan, Zhou
Chen, Bing
Li, Yanli
Zhong, Huanzi
Xie, Hailiang
Jie, Zhuye
Chen, Weineng
Tang, Shanmei
Xu, Xiaoqiang
Wang, Xiaokai
Cai, Xianghang
Liu, Sheng
Xia, Yan
Li, Jiyang
Qiao, Xingye
Al-Aama, Jumana Yousuf
Chen, Hua
Wang, Li
Wu, Qing-jun
Zhang, Fengchun
Zheng, Wenjie
Li, Yongzhe
Zhang, Mingrong
Luo, Guangwen
Xue, Wenbin
Xiao, Liang
Li, Jun
Chen, Wanting
Xu, Xun
Yin, Ye
Yang, Huanming
Wang, Jian
Kristiansen, Karsten
Liu, Liang
Li, Ting
Huang, Qingchun
Li, Yingrui
Wang, Jun
Title The oral and gut microbiomes are perturbed in rheumatoid arthritis and partly normalized after treatment
Journal name Nature Medicine   Check publisher's open access policy
ISSN 1546-170X
Publication date 2015-07-27
Sub-type Article (original research)
DOI 10.1038/nm.3914
Open Access Status Not Open Access
Volume 21
Issue 8
Start page 895
End page 905
Total pages 11
Place of publication New York, NY, United States
Publisher Nature Publishing Group
Language eng
Formatted abstract
We carried out metagenomic shotgun sequencing and a metagenome-wide association study (MGWAS) of fecal, dental and salivary samples from a cohort of individuals with rheumatoid arthritis (RA) and healthy controls. Concordance was observed between the gut and oral microbiomes, suggesting overlap in the abundance and function of species at different body sites. Dysbiosis was detected in the gut and oral microbiomes of RA patients, but it was partially resolved after RA treatment. Alterations in the gut, dental or saliva microbiome distinguished individuals with RA from healthy controls, were correlated with clinical measures and could be used to stratify individuals on the basis of their response to therapy. In particular, Haemophilus spp. were depleted in individuals with RA at all three sites and negatively correlated with levels of serum autoantibodies, whereas Lactobacillus salivarius was over-represented in individuals with RA at all three sites and was present in increased amounts in cases of very active RA. Functionally, the redox environment, transport and metabolism of iron, sulfur, zinc and arginine were altered in the microbiota of individuals with RA. Molecular mimicry of human antigens related to RA was also detectable. Our results establish specific alterations in the gut and oral microbiomes in individuals with RA and suggest potential ways of using microbiome composition for prognosis and diagnosis.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
Institute for Molecular Bioscience - Publications
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