Whole-genome and whole-exome sequencing of bladder cancer identifies frequent alterations in genes involved in sister chromatid cohesion and segregation

Guo, Guangwu, Sun, Xiaojuan, Chen, Chao, Wu, Song, Huang, Peide, Li, Zesong, Dean, Michael, Huang, Yi, Jia, Wenlong, Zhou, Quan, Tang, Aifa, Yang, Zuoquan, Li, Xianxin, Song, Pengfei, Zhao, Xiaokun, Ye, Rui, Zhang, Shiqiang, Lin, Zhao, Qi, Mingfu, Wan, Shengqing, Xie, Liangfu, Fan, Fan, Nickerson, Michael L., Zou, Xiangjun, Hu, Xueda, Xing, Li, Lv, Zhaojie, Mei, Hongbin, Gao, Shengjie, Liang, Chaozhao, Gao, Zhibo, Lu, Jingxiao, Yu, Yuan, Liu, Chunxiao, Li, Lin, Fang, Xiaodong, Jiang, Zhimao, Yang, Jie, Li, Cailing, Zhao, Xin, Chen, Jing, Zhang, Fang, Lai, Yongqi, Lin, Zheguang, Zhou, Fangjian, Chen, Hao, Chan, Hsiao Chang, Tsang, Shirley, Theodorescu, Dan, Li, Yingrui, Zhang, Xiuqing, Wang, Jian, Yang, Huanming, Gui, Yaoting, Wang, Jun and Cai, Zhiming (2013) Whole-genome and whole-exome sequencing of bladder cancer identifies frequent alterations in genes involved in sister chromatid cohesion and segregation. Nature Genetics, 45 12: 1459-1463. doi:10.1038/ng.2798


Author Guo, Guangwu
Sun, Xiaojuan
Chen, Chao
Wu, Song
Huang, Peide
Li, Zesong
Dean, Michael
Huang, Yi
Jia, Wenlong
Zhou, Quan
Tang, Aifa
Yang, Zuoquan
Li, Xianxin
Song, Pengfei
Zhao, Xiaokun
Ye, Rui
Zhang, Shiqiang
Lin, Zhao
Qi, Mingfu
Wan, Shengqing
Xie, Liangfu
Fan, Fan
Nickerson, Michael L.
Zou, Xiangjun
Hu, Xueda
Xing, Li
Lv, Zhaojie
Mei, Hongbin
Gao, Shengjie
Liang, Chaozhao
Gao, Zhibo
Lu, Jingxiao
Yu, Yuan
Liu, Chunxiao
Li, Lin
Fang, Xiaodong
Jiang, Zhimao
Yang, Jie
Li, Cailing
Zhao, Xin
Chen, Jing
Zhang, Fang
Lai, Yongqi
Lin, Zheguang
Zhou, Fangjian
Chen, Hao
Chan, Hsiao Chang
Tsang, Shirley
Theodorescu, Dan
Li, Yingrui
Zhang, Xiuqing
Wang, Jian
Yang, Huanming
Gui, Yaoting
Wang, Jun
Cai, Zhiming
Title Whole-genome and whole-exome sequencing of bladder cancer identifies frequent alterations in genes involved in sister chromatid cohesion and segregation
Journal name Nature Genetics   Check publisher's open access policy
ISSN 1061-4036
1546-1718
Publication date 2013-12-01
Year available 2013
Sub-type Letter to editor, brief commentary or brief communication
DOI 10.1038/ng.2798
Volume 45
Issue 12
Start page 1459
End page 1463
Total pages 5
Place of publication New York, NY, United States
Publisher Nature Publishing Group
Language eng
Formatted abstract
Bladder cancer is one of the most common cancers worldwide, with transitional cell carcinoma (TCC) being the predominant form. Here we report a genomic analysis of TCC by both whole-genome and whole-exome sequencing of 99 individuals with TCC. Beyond confirming recurrent mutations in genes previously identified as being mutated in TCC, we identified additional altered genes and pathways that were implicated in TCC. Notably, we discovered frequent alterations in STAG2 and ESPL1, two genes involved in the sister chromatid cohesion and segregation (SCCS) process. Furthermore, we also detected a recurrent fusion involving FGFR3 and TACC3, another component of SCCS, by transcriptome sequencing of 42 DNA-sequenced tumors. Overall, 32 of the 99 tumors (32%) harbored genetic alterations in the SCCS process. Our analysis provides evidence that genetic alterations affecting the SCCS process may be involved in bladder tumorigenesis and identifies a new therapeutic possibility for bladder cancer.
Q-Index Code CX
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Letter to editor, brief commentary or brief communication
Collection: School of Chemistry and Molecular Biosciences
 
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