The sequence and analysis of a Chinese pig genome

Fang, Xiaodong, Mu, Yulian, Huang, Zhiyong, Li, Yong, Han, Lijuan, Zhang, Yanfeng, Feng, Yue, Chen, Yuanxin, Jiang, Xuanting, Zhao, Wei, Sun, Xiaoqing, Xiong, Zhiqiang, Yang, Lan, Liu, Huan, Fan, Dingding, Mao, Likai, Ren, Lijie, Liu, Chuxin, Wang, Juan, Li, Kui, Wang, Guangbiao, Yang, Shulin, Lai, Liangxue, Zhang, Guojie, Li, Yingrui, Wang, Jun, Bolund, Lars, Yang, Huanming, Wang, Jian, Feng, Shutang, Li, Songgang and Du, Yutao (2012) The sequence and analysis of a Chinese pig genome. Gigascience, 1 . doi:10.1186/2047-217X-1-16

Author Fang, Xiaodong
Mu, Yulian
Huang, Zhiyong
Li, Yong
Han, Lijuan
Zhang, Yanfeng
Feng, Yue
Chen, Yuanxin
Jiang, Xuanting
Zhao, Wei
Sun, Xiaoqing
Xiong, Zhiqiang
Yang, Lan
Liu, Huan
Fan, Dingding
Mao, Likai
Ren, Lijie
Liu, Chuxin
Wang, Juan
Li, Kui
Wang, Guangbiao
Yang, Shulin
Lai, Liangxue
Zhang, Guojie
Li, Yingrui
Wang, Jun
Bolund, Lars
Yang, Huanming
Wang, Jian
Feng, Shutang
Li, Songgang
Du, Yutao
Title The sequence and analysis of a Chinese pig genome
Journal name Gigascience   Check publisher's open access policy
ISSN 2047-217X
Publication date 2012-11-15
Sub-type Article (original research)
DOI 10.1186/2047-217X-1-16
Open Access Status DOI
Volume 1
Total pages 11
Place of publication London, United Kingdom
Publisher BioMed Central
Language eng
Formatted abstract
The pig is an economically important food source, amounting to approximately 40% of all meat consumed worldwide. Pigs also serve as an important model organism because of their similarity to humans at the anatomical, physiological and genetic level, making them very useful for studying a variety of human diseases. A pig strain of particular interest is the miniature pig, specifically the Wuzhishan pig (WZSP), as it has been extensively inbred. Its high level of homozygosity offers increased ease for selective breeding for specific traits and a more straightforward understanding of the genetic changes that underlie its biological characteristics. WZSP also serves as a promising means for applications in surgery, tissue engineering, and xenotransplantation. Here, we report the sequencing and analysis of an inbreeding WZSP genome.

Our results reveal some unique genomic features, including a relatively high level of homozygosity in the diploid genome, an unusual distribution of heterozygosity, an over-representation of tRNA-derived transposable elements, a small amount of porcine endogenous retrovirus, and a lack of type C retroviruses. In addition, we carried out systematic research on gene evolution, together with a detailed investigation of the counterparts of human drug target genes.

Our results provide the opportunity to more clearly define the genomic character of pig, which could enhance our ability to create more useful pig models.
Keyword Wuzhishan pig
Transposable element
Endogenous retrovirus
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ
Additional Notes Article number 16

Document type: Journal Article
Sub-type: Article (original research)
Collection: Institute for Molecular Bioscience - Publications
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