A human gut microbial gene catalogue established by metagenomic sequencing

Qin, Junjie, Li, Ruiqiang, Raes, Jeroen, Arumugam, Manimozhiyan, Burgdorf, Kristoffer Solvsten, Manichanh, Chaysavanh, Nielsen, Trine, Pons, Nicolas, Levenez, Florence, Yamada, Takuji, Mende, Daniel R., Li, Junhua, Xu, Junming, Li, Shaochuan, Li, Dongfang, Cao, Jianjun, Wang, Bo, Liang, Huiqing, Zheng, Huisong, Xie, Yinlong, Tap, Julien, Lepage, Patricia, Bertalan, Marcelo, Batto, Jean-Michel, Hansen, Torben, Le Paslier, Denis, Linneberg, Allan, Nielsen, H. Bjorn, Pelletier, Eric, Renault, Pierre, Sicheritz-Ponten, Thomas, Turner, Keith, Zhu, Hongmei, Yu, Chang, Li, Shengting, Jian, Min, Zhou, Yan, Li, Yingrui, Zhang, Xiuqing, Li, Songgang, Qin, Nan, Yang, Huanming, Wang, Jian, Brunak, Soren, Dore, Joel, Guarner, Francisco, Kristiansen, Karsten, Pedersen, Oluf, Parkhill, Julian, Weissenbach, Jean, Bork, Peer, Ehrlich, S. Dusko and Wang, Jun (2010) A human gut microbial gene catalogue established by metagenomic sequencing. Nature, 464 7285: 59-65. doi:10.1038/nature08821

Author Qin, Junjie
Li, Ruiqiang
Raes, Jeroen
Arumugam, Manimozhiyan
Burgdorf, Kristoffer Solvsten
Manichanh, Chaysavanh
Nielsen, Trine
Pons, Nicolas
Levenez, Florence
Yamada, Takuji
Mende, Daniel R.
Li, Junhua
Xu, Junming
Li, Shaochuan
Li, Dongfang
Cao, Jianjun
Wang, Bo
Liang, Huiqing
Zheng, Huisong
Xie, Yinlong
Tap, Julien
Lepage, Patricia
Bertalan, Marcelo
Batto, Jean-Michel
Hansen, Torben
Le Paslier, Denis
Linneberg, Allan
Nielsen, H. Bjorn
Pelletier, Eric
Renault, Pierre
Sicheritz-Ponten, Thomas
Turner, Keith
Zhu, Hongmei
Yu, Chang
Li, Shengting
Jian, Min
Zhou, Yan
Li, Yingrui
Zhang, Xiuqing
Li, Songgang
Qin, Nan
Yang, Huanming
Wang, Jian
Brunak, Soren
Dore, Joel
Guarner, Francisco
Kristiansen, Karsten
Pedersen, Oluf
Parkhill, Julian
Weissenbach, Jean
Bork, Peer
Ehrlich, S. Dusko
Wang, Jun
Title A human gut microbial gene catalogue established by metagenomic sequencing
Journal name Nature   Check publisher's open access policy
ISSN 0028-0836
Publication date 2010-03-04
Year available 2015
Sub-type Article (original research)
DOI 10.1038/nature08821
Open Access Status Not yet assessed
Volume 464
Issue 7285
Start page 59
End page 65
Total pages 7
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Language eng
Abstract To understand the impact of gut microbes on human health and well-being it is crucial to assess their genetic potential. Here we describe the Illumina-based metagenomic sequencing, assembly and characterization of 3.3 million non-redundant microbial genes, derived from 576.7 gigabases of sequence, from faecal samples of 124 European individuals. The gene set, 150 times larger than the human gene complement, contains an overwhelming majority of the prevalent (more frequent) microbial genes of the cohort and probably includes a large proportion of the prevalent human intestinal microbial genes. The genes are largely shared among individuals of the cohort. Over 99% of the genes are bacterial, indicating that the entire cohort harbours between 1,000 and 1,150 prevalent bacterial species and each individual at least 160 such species, which are also largely shared. We define and describe the minimal gut metagenome and the minimal gut bacterial genome in terms of functions present in all individuals and most bacteria, respectively.
Keyword Microbiology
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID CP09/00049
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Institute for Molecular Bioscience - Publications
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