Genome sequencing and comparison of two nonhuman primate animal models, the cynomolgus and Chinese rhesus macaques

Yan, Guangmei, Zhang, Guojie, Fang, Xiaodong, Zhang, Yanfeng, Li, Cai, Ling, Fei, Cooper, David N., Li, Qiye, Li, Yan, van Gool, Alain J., Du, Hongli, Chen, Jiesi, Chen, Ronghua, Zhang, Pei, Huang, Zhiyong, Thompson, John R., Meng, Yuhuan, Bai, Yinqi, Wang, Jufang, Zhuo, Min, Wang, Tao, Huang, Ying, Wei, Liqiong, Li, Jianwen, Wang, Zhiwen, Hu, Haofu, Yang, Pengcheng, Le, Liang, Stenson, Peter D., Li, Bo, Liu, Xiaoming, Ball, Edward V., An, Na, Huang, Quanfei, Zhang, Yong, Fan, Wei, Zhang, Xiuqing, Li, Yingrui, Wang, Wen, Katze, Michael G., Su, Bing, Nielsen, Rasmus, Yang, Huanming, Wang, Jun, Wang, Xiaoning and Wang, Jian (2011) Genome sequencing and comparison of two nonhuman primate animal models, the cynomolgus and Chinese rhesus macaques. Nature Biotechnology, 29 11: 1019-1023. doi:10.1038/nbt.1992

Author Yan, Guangmei
Zhang, Guojie
Fang, Xiaodong
Zhang, Yanfeng
Li, Cai
Ling, Fei
Cooper, David N.
Li, Qiye
Li, Yan
van Gool, Alain J.
Du, Hongli
Chen, Jiesi
Chen, Ronghua
Zhang, Pei
Huang, Zhiyong
Thompson, John R.
Meng, Yuhuan
Bai, Yinqi
Wang, Jufang
Zhuo, Min
Wang, Tao
Huang, Ying
Wei, Liqiong
Li, Jianwen
Wang, Zhiwen
Hu, Haofu
Yang, Pengcheng
Le, Liang
Stenson, Peter D.
Li, Bo
Liu, Xiaoming
Ball, Edward V.
An, Na
Huang, Quanfei
Zhang, Yong
Fan, Wei
Zhang, Xiuqing
Li, Yingrui
Wang, Wen
Katze, Michael G.
Su, Bing
Nielsen, Rasmus
Yang, Huanming
Wang, Jun
Wang, Xiaoning
Wang, Jian
Title Genome sequencing and comparison of two nonhuman primate animal models, the cynomolgus and Chinese rhesus macaques
Journal name Nature Biotechnology   Check publisher's open access policy
ISSN 1087-0156
Publication date 2011-10-16
Year available 2011
Sub-type Letter to editor, brief commentary or brief communication
DOI 10.1038/nbt.1992
Open Access Status Not yet assessed
Volume 29
Issue 11
Start page 1019
End page 1023
Total pages 5
Place of publication New York, NY, United States
Publisher Nature Publishing Group
Language eng
Formatted abstract
The nonhuman primates most commonly used in medical research are from the genus Macaca. To better understand the genetic differences between these animal models, we present high-quality draft genome sequences from two macaque species, the cynomolgus/crab-eating macaque and the Chinese rhesus macaque. Comparison with the previously sequenced Indian rhesus macaque reveals that all three macaques maintain abundant genetic heterogeneity, including millions of single-nucleotide substitutions and many insertions, deletions and gross chromosomal rearrangements. By assessing genetic regions with reduced variability, we identify genes in each macaque species that may have experienced positive selection. Genetic divergence patterns suggest that the cynomolgus macaque genome has been shaped by introgression after hybridization with the Chinese rhesus macaque. Macaque genes display a high degree of sequence similarity with human disease gene orthologs and drug targets. However, we identify several putatively dysfunctional genetic differences between the three macaque species, which may explain functional differences between them previously observed in clinical studies.
Q-Index Code CX
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Letter to editor, brief commentary or brief communication
Collection: School of Chemistry and Molecular Biosciences
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