Frequent mutations of genes encoding ubiquitin-mediated proteolysis pathway components in clear cell renal cell carcinoma

Guo, Guangwu, Gui, Yaoting, Gao, Shengjie, Tang, Aifa, Hu, Xueda, Huang, Yi, Jia, Wenlong, Li, Zesong, He, Minghui, Sun, Liang, Song, Pengfei, Sun, Xiaojuan, Zhao, Xiaokun, Yang, Sangming, Liang, Chaozhao, Wan, Shengqing, Zhou, Fangjian, Chen, Chao, Zhu, Jialou, Li, Xianxin, Jian, Minghan, Zhou, Liang, Ye, Rui, Huang, Peide, Chen, Jing, Jiang, Tao, Liu, Xiao, Wang, Yong, Zou, Jing, Jiang, Zhimao, Wu, Renhua, Wu, Song, Fan, Fan, Zhang, Zhongfu, Liu, Lin, Yang, Ruilin, Liu, Xingwang, Wu, Haibo, Yin, Weihua, Zhao, Xia, Liu, Yuchen, Peng, Huanhuan, Jiang, Binghua, Feng, Qingxin, Li, Cailing, Xie, Jun, Lu, Jingxiao, Kristiansen, Karsten, Li, Yingrui, Zhang, Xiuqing, Li, Songgang, Wang, Jian, Yang, Huanming, Cai, Zhiming and Wang, Jun (2012) Frequent mutations of genes encoding ubiquitin-mediated proteolysis pathway components in clear cell renal cell carcinoma. Nature Genetics, 44 1: 17-19. doi:10.1038/ng.1014


Author Guo, Guangwu
Gui, Yaoting
Gao, Shengjie
Tang, Aifa
Hu, Xueda
Huang, Yi
Jia, Wenlong
Li, Zesong
He, Minghui
Sun, Liang
Song, Pengfei
Sun, Xiaojuan
Zhao, Xiaokun
Yang, Sangming
Liang, Chaozhao
Wan, Shengqing
Zhou, Fangjian
Chen, Chao
Zhu, Jialou
Li, Xianxin
Jian, Minghan
Zhou, Liang
Ye, Rui
Huang, Peide
Chen, Jing
Jiang, Tao
Liu, Xiao
Wang, Yong
Zou, Jing
Jiang, Zhimao
Wu, Renhua
Wu, Song
Fan, Fan
Zhang, Zhongfu
Liu, Lin
Yang, Ruilin
Liu, Xingwang
Wu, Haibo
Yin, Weihua
Zhao, Xia
Liu, Yuchen
Peng, Huanhuan
Jiang, Binghua
Feng, Qingxin
Li, Cailing
Xie, Jun
Lu, Jingxiao
Kristiansen, Karsten
Li, Yingrui
Zhang, Xiuqing
Li, Songgang
Wang, Jian
Yang, Huanming
Cai, Zhiming
Wang, Jun
Title Frequent mutations of genes encoding ubiquitin-mediated proteolysis pathway components in clear cell renal cell carcinoma
Journal name Nature Genetics   Check publisher's open access policy
ISSN 1061-4036
1546-1718
Publication date 2012-01-01
Year available 2011
Sub-type Letter to editor, brief commentary or brief communication
DOI 10.1038/ng.1014
Open Access Status Not yet assessed
Volume 44
Issue 1
Start page 17
End page 19
Total pages 3
Place of publication New York, NY, United States
Publisher Nature Publishing Group
Language eng
Formatted abstract
We sequenced whole exomes of ten clear cell renal cell carcinomas (ccRCCs) and performed a screen of ∼1,100 genes in 88 additional ccRCCs, from which we discovered 12 previously unidentified genes mutated at elevated frequencies in ccRCC. Notably, we detected frequent mutations in the ubiquitin-mediated proteolysis pathway (UMPP), and alterations in the UMPP were significantly associated with overexpression of HIF1α and HIF2α in the tumors (P = 0.01 and 0.04, respectively). Our findings highlight the potential contribution of UMPP to ccRCC tumorigenesis through the activation of the hypoxia regulatory network.
Q-Index Code CX
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Letter to editor, brief commentary or brief communication
Collection: School of Chemistry and Molecular Biosciences
 
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