Sequencing-based approach identified three new susceptibility loci for psoriasis

Sheng, Yujun, Jin, Xin, Xu, Jinhua, Gao, Jinping, Du, Xiaoqing, Duan, Dawei, Li, Bing, Zhao, Jinhua, Zhan, Wenying, Tang, Huayang, Tang, Xianfa, Li, Yang, Cheng, Hui, Zuo, Xianbo, Mei, Junpu, Zhou, Fusheng, Liang, Bo, Chen, Gang, Shen, Changbing, Cui, Hongzhou, Zhang, Xiaoguang, Zhang, Change, Wang, Wenjun, Zheng, Xiaodong, Fan, Xing, Wang, Zaixing, Xiao, Fengli, Cui, Yong, Li, Yingrui, Wang, Jun, Yang, Sen, Xu, Lei, Sun, Liangdan and Zhang, Xuejun (2014) Sequencing-based approach identified three new susceptibility loci for psoriasis. Nature Communications, 5 1-6. doi:10.1038/ncomms5331

Author Sheng, Yujun
Jin, Xin
Xu, Jinhua
Gao, Jinping
Du, Xiaoqing
Duan, Dawei
Li, Bing
Zhao, Jinhua
Zhan, Wenying
Tang, Huayang
Tang, Xianfa
Li, Yang
Cheng, Hui
Zuo, Xianbo
Mei, Junpu
Zhou, Fusheng
Liang, Bo
Chen, Gang
Shen, Changbing
Cui, Hongzhou
Zhang, Xiaoguang
Zhang, Change
Wang, Wenjun
Zheng, Xiaodong
Fan, Xing
Wang, Zaixing
Xiao, Fengli
Cui, Yong
Li, Yingrui
Wang, Jun
Yang, Sen
Xu, Lei
Sun, Liangdan
Zhang, Xuejun
Title Sequencing-based approach identified three new susceptibility loci for psoriasis
Journal name Nature Communications   Check publisher's open access policy
ISSN 2041-1723
Publication date 2014-07-09
Sub-type Article (original research)
DOI 10.1038/ncomms5331
Open Access Status File (Publisher version)
Volume 5
Start page 1
End page 6
Total pages 6
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Language eng
Abstract In a previous large-scale exome sequencing analysis for psoriasis, we discovered seven common and low-frequency missense variants within six genes with genome-wide significance. Here we describe an in-depth analysis of noncoding variants based on sequencing data (10,727 cases and 10,582 controls) with replication in an independent cohort of Han Chinese individuals consisting of 4,480 cases and 6,521 controls to identify additional psoriasis susceptibility loci. We confirmed four known psoriasis susceptibility loci (IL12B, IFIH1, ERAP1 and RNF114; 2.30 × 1020 ≤P≤2.41 × 107) and identified three new susceptibility loci: 4q24 (NFKB1) at rs1020760 (P=2.19 × 108), 12p13.3 (CD27-LAG3) at rs758739 (P=4.08 × 108) and 17q12 (IKZF3) at rs10852936 (P=1.96 × 108). Two suggestive loci, 3p21.31 and 17q25, are also identified with P<1.00 × 106. The results of this study increase the number of confirmed psoriasis risk loci and provide novel insight into the pathogenesis of psoriasis.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Institute for Molecular Bioscience - Publications
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