Molecular signatures of major depression

Cai, Na, Chang, Simon, Li, Yihan, Li, Qibin, Hu, Jingchu, Liang, Jieqin, Song, Li, Kretzschmar, Warren, Gan, Xiangchao, Nicod, Jerome, Rivera, Margarita, Deng, Hong, Du, Bo, Li, Keqing, Sang, Wenhu, Gao, Jingfang, Gao, Shugui, Ha, Baowei, Ho, Hung-Yao, Hu, Chunmei, Hu, Jian, Hu, Zhenfei, Huang, Guoping, Jiang, Guoqing, Jiang, Tao, Jin, Wei, Li, Gongying, Li, Kan, Li, Yi, Li, Yingrui, Li, Youhui, Lin, Yu-Ting, Liu, Lanfen, Liu, Tiebang, Liu, Ying, Liu, Yuan, Lu, Yao, Lv, Luxian, Meng, Huaqing, Qian, Puyi, Sang, Hong, Shen, Jianhua, Shi, Jianguo, Sun, Jing, Tao, Ming, Wang, Gang, Wang, Guangbiao, Wang, Jian, Wang, Linmao, Wang, Xueyi, Wang, Xumei, Yang, Huanming, Yang, Lijun, Yin, Ye, Zhang, Jinbei, Zhang, Kerang, Sun, Ning, Zhang, Wei, Zhang, Xiuqing, Zhang, Zhen, Zhong, Hui, Breen, Gerome, Wang, Jun, Marchini, Jonathan, Chen, Yiping, Xu, Qi, Xu, Xun, Mott, Richard, Huang, Guo-Jen, Kendler, Kenneth and Flintl, Jonathan (2015) Molecular signatures of major depression. Current Biology, 25 9: 1146-1156. doi:10.1016/j.cub.2015.03.008


Author Cai, Na
Chang, Simon
Li, Yihan
Li, Qibin
Hu, Jingchu
Liang, Jieqin
Song, Li
Kretzschmar, Warren
Gan, Xiangchao
Nicod, Jerome
Rivera, Margarita
Deng, Hong
Du, Bo
Li, Keqing
Sang, Wenhu
Gao, Jingfang
Gao, Shugui
Ha, Baowei
Ho, Hung-Yao
Hu, Chunmei
Hu, Jian
Hu, Zhenfei
Huang, Guoping
Jiang, Guoqing
Jiang, Tao
Jin, Wei
Li, Gongying
Li, Kan
Li, Yi
Li, Yingrui
Li, Youhui
Lin, Yu-Ting
Liu, Lanfen
Liu, Tiebang
Liu, Ying
Liu, Yuan
Lu, Yao
Lv, Luxian
Meng, Huaqing
Qian, Puyi
Sang, Hong
Shen, Jianhua
Shi, Jianguo
Sun, Jing
Tao, Ming
Wang, Gang
Wang, Guangbiao
Wang, Jian
Wang, Linmao
Wang, Xueyi
Wang, Xumei
Yang, Huanming
Yang, Lijun
Yin, Ye
Zhang, Jinbei
Zhang, Kerang
Sun, Ning
Zhang, Wei
Zhang, Xiuqing
Zhang, Zhen
Zhong, Hui
Breen, Gerome
Wang, Jun
Marchini, Jonathan
Chen, Yiping
Xu, Qi
Xu, Xun
Mott, Richard
Huang, Guo-Jen
Kendler, Kenneth
Flintl, Jonathan
Title Molecular signatures of major depression
Journal name Current Biology   Check publisher's open access policy
ISSN 0960-9822
1879-0445
Publication date 2015-05-04
Year available 2015
Sub-type Article (original research)
DOI 10.1016/j.cub.2015.03.008
Open Access Status DOI
Volume 25
Issue 9
Start page 1146
End page 1156
Total pages 11
Place of publication Cambridge, Massachusetts, United States
Publisher Cell Press
Language eng
Formatted abstract
Adversity, particularly in early life, can cause illness. Clues to the responsible mechanisms may lie with the discovery of molecular signatures of stress, some of which include alterations to an individual’s somatic genome. Here, using genome sequences from 11,670 women, we observed a highly significant association between a stress-related disease, major depression, and the amount of mtDNA (p = 9.00 × 10−42, odds ratio 1.33 [95% confidence interval [CI] = 1.29–1.37]) and telomere length (p = 2.84 × 10−14, odds ratio 0.85 [95% CI = 0.81–0.89]). While both telomere length and mtDNA amount were associated with adverse life events, conditional regression analyses showed the molecular changes were contingent on the depressed state. We tested this hypothesis with experiments in mice, demonstrating that stress causes both molecular changes, which are partly reversible and can be elicited by the administration of corticosterone. Together, these results demonstrate that changes in the amount of mtDNA and telomere length are consequences of stress and entering a depressed state. These findings identify increased amounts of mtDNA as a molecular marker of MD and have important implications for understanding how stress causes the disease.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
Institute for Molecular Bioscience - Publications
 
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