The duck genome and transcriptome provide insight into an avian influenza virus reservoir species

Huang, Yinhua, Li, Yingrui, Burt, David W., Chen, Hualan, Zhang, Yong, Qian, Wubin, Kim, Heebal, Gan, Shangquan, Zhao, Yiqiang, Li, Jianwen, Yi, Kang, Feng, Huapeng, Zhu, Pengyang, Li, Bo, Liu, Qiuyue, Fairley, Suan, Magor, Katharine E., Du, Zhenlin, Hu, Xiaoxiang, Goodman, Laurie, Tafer, Hakim, Vignal, Alain, Lee, Taeheon, Kim, Kyu-Won, Sheng, Zheya, An, Yang, Searle, Steve, Herrero, Javier, Groenen, Martien A. M., Crooijmans, Richard P. M. A., Faraut, Thomas, Cai, Qingle, Webster, Robert G., Aldridge, Jerry R., Warren, Wesley C., Bartschat, Sebastian, Kehr, Stephanie, Marz, Manja, Stadler, Peter F., Smith, Jacqueline, Kraus, Robert H. S., Zhao, Yaofeng, Ren, Liming, Fei, Jing, Morisson, Mireille, Kaiser, Pete, Griffin, Darren K., Rao, Man, Pitel, Frederique, Wang, Jun and Li, Ning (2013) The duck genome and transcriptome provide insight into an avian influenza virus reservoir species. Nature Genetics, 45 7: 776-783. doi:10.1038/ng.2657


Author Huang, Yinhua
Li, Yingrui
Burt, David W.
Chen, Hualan
Zhang, Yong
Qian, Wubin
Kim, Heebal
Gan, Shangquan
Zhao, Yiqiang
Li, Jianwen
Yi, Kang
Feng, Huapeng
Zhu, Pengyang
Li, Bo
Liu, Qiuyue
Fairley, Suan
Magor, Katharine E.
Du, Zhenlin
Hu, Xiaoxiang
Goodman, Laurie
Tafer, Hakim
Vignal, Alain
Lee, Taeheon
Kim, Kyu-Won
Sheng, Zheya
An, Yang
Searle, Steve
Herrero, Javier
Groenen, Martien A. M.
Crooijmans, Richard P. M. A.
Faraut, Thomas
Cai, Qingle
Webster, Robert G.
Aldridge, Jerry R.
Warren, Wesley C.
Bartschat, Sebastian
Kehr, Stephanie
Marz, Manja
Stadler, Peter F.
Smith, Jacqueline
Kraus, Robert H. S.
Zhao, Yaofeng
Ren, Liming
Fei, Jing
Morisson, Mireille
Kaiser, Pete
Griffin, Darren K.
Rao, Man
Pitel, Frederique
Wang, Jun
Li, Ning
Title The duck genome and transcriptome provide insight into an avian influenza virus reservoir species
Journal name Nature Genetics   Check publisher's open access policy
ISSN 1061-4036
1546-1718
Publication date 2013-06-09
Sub-type Article (original research)
DOI 10.1038/ng.2657
Open Access Status DOI
Volume 45
Issue 7
Start page 776
End page 783
Total pages 8
Place of publication New York, NY United States
Publisher Nature Publishing Group
Language eng
Formatted abstract
The duck (Anas platyrhynchos) is one of the principal natural hosts of influenza A viruses. We present the duck genome sequence and perform deep transcriptome analyses to investigate immune-related genes. Our data indicate that the duck possesses a contractive immune gene repertoire, as in chicken and zebra finch, and this repertoire has been shaped through lineage-specific duplications. We identify genes that are responsive to influenza A viruses using the lung transcriptomes of control ducks and ones that were infected with either a highly pathogenic (A/duck/Hubei/49/05) or a weakly pathogenic (A/goose/Hubei/65/05) H5N1 virus. Further, we show how the duck's defense mechanisms against influenza infection have been optimized through the diversification of its β-defensin and butyrophilin-like repertoires. These analyses, in combination with the genomic and transcriptomic data, provide a resource for characterizing the interaction between host and influenza viruses.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Institute for Molecular Bioscience - Publications
 
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