A metagenome-wide association study of gut microbiota in type 2 diabetes

Qin, Junjie, Li, Yingrui, Cai, Zhiming, Li, Shenghui, Zhu, Jianfeng, Zhang, Fan, Liang, Suisha, Zhang, Wenwei, Guan, Yuanlin, Shen, Dongqian, Peng, Yangqing, Zhang, Dongya, Jie, Zhuye, Wu, Wenxian, Qin, Youwen, Xue, Wenbin, Li, Junhua, Han, Lingchuan, Lu, Donghui, Wu, Peixian, Dai, Yali, Sun, Xiaojuan, Li, Zesong, Tang, Aifa, Zhong, Shilong, Li, Xiaoping, Chen, Weineng, Xu, Ran, Wang, Mingbang, Feng, Qiang, Gong, Meihua, Yu, Jing, Zhang, Yanyan, Zhang, Ming, Hansen, Torben, Sanchez, Gaston, Raes, Jeroen, Falony, Gwen, Okuda, Shujiro, Almeida, Mathieu, LeChatelier, Emmanuelle, Renault, Pierre, Pons, Nicolas, Batto, Jean-Michel, Zhang, Zhaoxi, Chen, Hua, Yang, Ruifu, Zheng, Weimou, Li, Songgang, Yang, Huanming, Wang, Jian, Ehrlich, S. Dusko, Nielsen, Rasmus, Pedersen, Oluf, Kristiansen, Karsten and Wang, Jun (2012) A metagenome-wide association study of gut microbiota in type 2 diabetes. Nature, 490 7418: 55-60. doi:10.1038/nature11450

Author Qin, Junjie
Li, Yingrui
Cai, Zhiming
Li, Shenghui
Zhu, Jianfeng
Zhang, Fan
Liang, Suisha
Zhang, Wenwei
Guan, Yuanlin
Shen, Dongqian
Peng, Yangqing
Zhang, Dongya
Jie, Zhuye
Wu, Wenxian
Qin, Youwen
Xue, Wenbin
Li, Junhua
Han, Lingchuan
Lu, Donghui
Wu, Peixian
Dai, Yali
Sun, Xiaojuan
Li, Zesong
Tang, Aifa
Zhong, Shilong
Li, Xiaoping
Chen, Weineng
Xu, Ran
Wang, Mingbang
Feng, Qiang
Gong, Meihua
Yu, Jing
Zhang, Yanyan
Zhang, Ming
Hansen, Torben
Sanchez, Gaston
Raes, Jeroen
Falony, Gwen
Okuda, Shujiro
Almeida, Mathieu
LeChatelier, Emmanuelle
Renault, Pierre
Pons, Nicolas
Batto, Jean-Michel
Zhang, Zhaoxi
Chen, Hua
Yang, Ruifu
Zheng, Weimou
Li, Songgang
Yang, Huanming
Wang, Jian
Ehrlich, S. Dusko
Nielsen, Rasmus
Pedersen, Oluf
Kristiansen, Karsten
Wang, Jun
Title A metagenome-wide association study of gut microbiota in type 2 diabetes
Journal name Nature   Check publisher's open access policy
ISSN 0028-0836
Publication date 2012-10-04
Year available 2012
Sub-type Article (original research)
DOI 10.1038/nature11450
Open Access Status Not yet assessed
Volume 490
Issue 7418
Start page 55
End page 60
Total pages 6
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Language eng
Abstract Assessment and characterization of gut microbiota has become a major research area in human disease, including type 2 diabetes, the most prevalent endocrine disease worldwide. To carry out analysis on gut microbial content in patients with type 2 diabetes, we developed a protocol for a metagenome-wide association study (MGWAS) and undertook a two-stage MGWAS based on deep shotgun sequencing of the gut microbial DNA from 345 Chinese individuals. We identified and validated approximately 60,000 type-2-diabetes-associated markers and established the concept of a metagenomic linkage group, enabling taxonomic species-level analyses. MGWAS analysis showed that patients with type 2 diabetes were characterized by a moderate degree of gut microbial dysbiosis, a decrease in the abundance of some universal butyrate-producing bacteria and an increase in various opportunistic pathogens, as well as an enrichment of other microbial functions conferring sulphate reduction and oxidative stress resistance. An analysis of 23 additional individuals demonstrated that these gut microbial markers might be useful for classifying type 2 diabetes.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Chemistry and Molecular Biosciences
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