Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder

Gui, Yaoting, Guo, Guangwu, Huang, Yi, Hu, Xueda, Tang, Aifa, Gao, Shengjie, Wu, Renhua, Chen, Chao, Li, Xianxin, Zhou, Liang, He, Minghui, Li, Zesong, Sun, Xiaojuan, Jia, Wenlong, Chen, Jinnong, Yang, Shangming, Zhou, Fangjian, Zhao, Xiaokun, Wan, Shengqing, Ye, Rui, Liang, Chaozhao, Liu, Zhisheng, Huang, Peide, Liu, Chunxiao, Jiang, Hui, Wang, Yong, Zheng, Hancheng, Sun, Liang, Liu, Xingwang, Jiang, Zhimao, Feng, Dafei, Chen, Jing, Wu, Song, Zou, Jing, Zhang, Zhongfu, Yang, Ruilin, Zhao, Jun, Xu, Congjie, Yin, Weihua, Guan, Zhichen, Ye, Jiongxian, Zhang, Hong, Li, Jingxiang, Kristiansen, Karsten, Nickerson, Michael L., Theodorescu, Dan, Li, Yingrui, Zhang, Xiuqing, Li, Songgang, Wang, Jian, Yang, Huanming, Wang, Jun and Cai, Zhiming (2011) Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder. Nature Genetics, 43 9: 875-878. doi:10.1038/ng.907

Author Gui, Yaoting
Guo, Guangwu
Huang, Yi
Hu, Xueda
Tang, Aifa
Gao, Shengjie
Wu, Renhua
Chen, Chao
Li, Xianxin
Zhou, Liang
He, Minghui
Li, Zesong
Sun, Xiaojuan
Jia, Wenlong
Chen, Jinnong
Yang, Shangming
Zhou, Fangjian
Zhao, Xiaokun
Wan, Shengqing
Ye, Rui
Liang, Chaozhao
Liu, Zhisheng
Huang, Peide
Liu, Chunxiao
Jiang, Hui
Wang, Yong
Zheng, Hancheng
Sun, Liang
Liu, Xingwang
Jiang, Zhimao
Feng, Dafei
Chen, Jing
Wu, Song
Zou, Jing
Zhang, Zhongfu
Yang, Ruilin
Zhao, Jun
Xu, Congjie
Yin, Weihua
Guan, Zhichen
Ye, Jiongxian
Zhang, Hong
Li, Jingxiang
Kristiansen, Karsten
Nickerson, Michael L.
Theodorescu, Dan
Li, Yingrui
Zhang, Xiuqing
Li, Songgang
Wang, Jian
Yang, Huanming
Wang, Jun
Cai, Zhiming
Title Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder
Journal name Nature Genetics   Check publisher's open access policy
ISSN 1061-4036
Publication date 2011-09-01
Year available 2011
Sub-type Article (original research)
DOI 10.1038/ng.907
Open Access Status Not yet assessed
Volume 43
Issue 9
Start page 875
End page 878
Total pages 4
Place of publication New York, NY, United States
Publisher Nature Publishing Group
Language eng
Formatted abstract
Transitional cell carcinoma (TCC) is the most common type of bladder cancer. Here we sequenced the exomes of nine individuals with TCC and screened all the somatically mutated genes in a prevalence set of 88 additional individuals with TCC with different tumor stages and grades. In our study, we discovered a variety of genes previously unknown to be mutated in TCC. Notably, we identified genetic aberrations of the chromatin remodeling genes (UTX, MLL-MLL3, CREBBP-EP300, NCOR1, ARID1A and CHD6) in 59% of our 97 subjects with TCC. Of these genes, we showed UTX to be altered substantially more frequently in tumors of low stages and grades, highlighting its potential role in the classification and diagnosis of bladder cancer. Our results provide an overview of the genetic basis of TCC and suggest that aberration of chromatin regulation might be a hallmark of bladder cancer.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Chemistry and Molecular Biosciences
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