Neurexin-1 regulates sleep and synaptic plasticity in Drosophila melanogaster

Larkin, Aoife, Chen, Ming-Yu, Kirszenblat, Leonie, Reinhard, Judith, van Swinderen, Bruno and Claudianos, Charles (2015) Neurexin-1 regulates sleep and synaptic plasticity in Drosophila melanogaster. European Journal of Neuroscience, 42 7: 2455-2466. doi:10.1111/ejn.13023

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Author Larkin, Aoife
Chen, Ming-Yu
Kirszenblat, Leonie
Reinhard, Judith
van Swinderen, Bruno
Claudianos, Charles
Title Neurexin-1 regulates sleep and synaptic plasticity in Drosophila melanogaster
Journal name European Journal of Neuroscience   Check publisher's open access policy
ISSN 1460-9568
Publication date 2015-08-19
Year available 2015
Sub-type Article (original research)
DOI 10.1111/ejn.13023
Open Access Status File (Author Post-print)
Volume 42
Issue 7
Start page 2455
End page 2466
Total pages 12
Place of publication West Sussex, United Kingdom
Publisher Wiley-Blackwell Publishing
Language eng
Formatted abstract
Neurexins are cell adhesion molecules that are important for synaptic plasticity and homeostasis, although links to sleep have not yet been investigated. We examined the effects of neurexin-1 perturbation on sleep in Drosophila, showing that neurexin-1 nulls displayed fragmented sleep and altered circadian rhythm. Conversely, the over-expression of neurexin-1 could increase and consolidate night-time sleep. This was not solely due to developmental effects as it could be induced acutely in adulthood, and was coupled with evidence of synaptic growth. The timing of over-expression could differentially impact sleep patterns, with specific night-time effects. These results show that neurexin-1 was dynamically involved in synaptic plasticity and sleep in Drosophila. Neurexin-1 and a number of its binding partners have been repeatedly associated with mental health disorders, including autism spectrum disorders, schizophrenia and Tourette syndrome, all of which are also linked to altered sleep patterns. How and when plasticity-related proteins such as neurexin-1 function during sleep can provide vital information on the interaction between synaptic homeostasis and sleep, paving the way for more informed treatments of human disorders.
Keyword Autism
Circadian rhythm
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2016 Collection
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Citation counts: TR Web of Science Citation Count  Cited 9 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 9 times in Scopus Article | Citations
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