S100B protein as a screening tool for computed tomography findings after mild traumatic brain injury: systematic review and meta-analysis

Heidari, Kamran, Vafaee, Ali, Rastekenari, Alireza M., Taghizadeh, Mehrdad, Shad, Ensieh G., Eley, Rob, Sinnott, Michael and Asadollahi, Shadi (2015) S100B protein as a screening tool for computed tomography findings after mild traumatic brain injury: systematic review and meta-analysis. Brain Injury, 29 10: 1146-1157. doi:10.3109/02699052.2015.1037349


Author Heidari, Kamran
Vafaee, Ali
Rastekenari, Alireza M.
Taghizadeh, Mehrdad
Shad, Ensieh G.
Eley, Rob
Sinnott, Michael
Asadollahi, Shadi
Title S100B protein as a screening tool for computed tomography findings after mild traumatic brain injury: systematic review and meta-analysis
Journal name Brain Injury   Check publisher's open access policy
ISSN 1362-301X
0269-9052
Publication date 2015-08-24
Year available 2015
Sub-type Critical review of research, literature review, critical commentary
DOI 10.3109/02699052.2015.1037349
Open Access Status Not Open Access
Volume 29
Issue 10
Start page 1146
End page 1157
Total pages 12
Place of publication London, United Kingdom
Publisher Informa Healthcare
Language eng
Subject 3204 Developmental and Educational Psychology
1201 Arts and Humanities (miscellaneous)
2728 Clinical Neurology
Abstract To determine whether S100B protein in serum can predict intracranial lesions on computed tomography (CT) scan after mild traumatic brain injury (MTBI).Research design: Systematic review and meta-analysisMethods and procedures: A literature search was conducted using Medline, Embase, Cochrane, Google Scholar, CINAHL, SUMSearch, Bandolier, Trip databases, bibliographies from identified articles and review article references. Eligible articles were defined as observational studies including patients with MTBI who underwent post-traumatic head CT scan and assessing the screening role of S100B protein.Main outcomes and results: There was a significant positive association between S100B protein concentration and positive CT scan (22 studies, SMD = 1.92, 95% CI = 1.29-2.45, I = 100%; p < 0.001). The pooled sensitivity and specificity values for a cut-point range = 0.16-0.20 μg L were 98.65 (95% CI = 95.53-101.77; I = 0.0%) and 50.69 (95% CI = 40.69-60.69; I = 76.3%), respectively. The threshold for serum S100B protein with 99.63 (95% CI = 96.00-103.25; I = 0.0%) sensitivity and 46.94 (95% CI = 39.01-54.87; I = 95.5%) specificity was > 0.20 μg L.Conclusions: After MTBI, serum S100B protein levels are significantly associated with the presence of intracranial lesions on CT scan. Measuring the protein could be useful in screening high risk MTBI patients and decreasing unnecessary CT examinations.
Formatted abstract
Primary objective:  To determine whether S100B protein in serum can predict intracranial lesions on computed tomography (CT) scan after mild traumatic brain injury (MTBI).

Research design:  Systematic review and meta-analysis

Methods and procedures:  A literature search was conducted using Medline, Embase, Cochrane, Google Scholar, CINAHL, SUMSearch, Bandolier, Trip databases, bibliographies from identified articles and review article references. Eligible articles were defined as observational studies including patients with MTBI who underwent post-traumatic head CT scan and assessing the screening role of S100B protein.

Main outcomes and results:  There was a significant positive association between S100B protein concentration and positive CT scan (22 studies, SMD = 1.92, 95% CI = 1.29–2.45, I2 = 100%; p < 0.001). The pooled sensitivity and specificity values for a cut-point range = 0.16–0.20 µg L−1 were 98.65 (95% CI = 95.53–101.77; I2 = 0.0%) and 50.69 (95% CI = 40.69–60.69; I2 = 76.3%), respectively. The threshold for serum S100B protein with 99.63 (95% CI = 96.00–103.25; I2 = 0.0%) sensitivity and 46.94 (95% CI = 39.01–54.87; I2 = 95.5%) specificity was > 0.20 µg L−1.

Conclusions:  After MTBI, serum S100B protein levels are significantly associated with the presence of intracranial lesions on CT scan. Measuring the protein could be useful in screening high risk MTBI patients and decreasing unnecessary CT examinations.
Keyword Brain injuries
Computed tomography
Diagnosis
Meta-analysis
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2016 Collection
School of Medicine Publications
 
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