The intestinal microbiome in human disease and how it relates to arthritis and spondyloarthritis

Costello, Mary-Ellen, Robinson, Philip C., Benham, Helen and Brown, Matthew A. (2015) The intestinal microbiome in human disease and how it relates to arthritis and spondyloarthritis. Best Practice and Research: Clinical Rheumatology, 29 2: 202-212. doi:10.1016/j.berh.2015.08.001


Author Costello, Mary-Ellen
Robinson, Philip C.
Benham, Helen
Brown, Matthew A.
Title The intestinal microbiome in human disease and how it relates to arthritis and spondyloarthritis
Journal name Best Practice and Research: Clinical Rheumatology   Check publisher's open access policy
ISSN 1532-1770
1521-6942
Publication date 2015-01-01
Year available 2015
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.berh.2015.08.001
Open Access Status Not Open Access
Volume 29
Issue 2
Start page 202
End page 212
Total pages 11
Place of publication Kidlington, Oxford United Kingdom
Publisher Bailliere Tindall
Language eng
Subject 2745 Rheumatology
Abstract Humans and microbes have developed a symbiotic relationship over time, and alterations in this symbiotic relationship have been linked to several immune mediated diseases such as inflammatory bowel disease, type 1 diabetes and spondyloarthropathies. Improvements in sequencing technologies, coupled with a renaissance in 16S rRNA gene based community profiling, have enabled the characterization of microbiomes throughout the body including the gut. Improved characterization and understanding of the human gut microbiome means the gut flora is progressively being explored as a target for novel therapies including probiotics and faecal microbiota transplants. These innovative therapies are increasingly used for patients with debilitating conditions where conventional treatments have failed. This review discusses the current understanding of the interplay between host genetics and the gut microbiome in the pathogenesis of spondyloarthropathies, and how this may relate to potential therapies for these conditions.
Keyword Intestinal microbiome
Spondyloarthritis
Faecal microbiota transplant
Dysbiosis
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Queensland Brain Institute Publications
Official 2016 Collection
Centre for Neurogenetics and Statistical Genomics Publications
School of Medicine Publications
UQ Diamantina Institute Publications
 
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