Genome wide association for the outcome of fixed time artificial insemination of Brahman heifers in northern Australia

Porto-Neto, Laercio R, Edwards, Sophia, Fortes, Marina R.S, Lehnert, Sigrid A, Reverter, Antonio and McGowan, Michael (2015) Genome wide association for the outcome of fixed time artificial insemination of Brahman heifers in northern Australia. Journal of Animal Science, 93 11: 5119-5127. doi:10.2527/jas2015-9401

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Author Porto-Neto, Laercio R
Edwards, Sophia
Fortes, Marina R.S
Lehnert, Sigrid A
Reverter, Antonio
McGowan, Michael
Title Genome wide association for the outcome of fixed time artificial insemination of Brahman heifers in northern Australia
Journal name Journal of Animal Science   Check publisher's open access policy
ISSN 1525-3163
Publication date 2015-01-01
Year available 2015
Sub-type Article (original research)
DOI 10.2527/jas2015-9401
Open Access Status Not Open Access
Volume 93
Issue 11
Start page 5119
End page 5127
Total pages 19
Place of publication Champaign, United States
Publisher American Society of Animal Science
Language eng
Formatted abstract
Fixed time artificial insemination (FTAI) is a powerful tool for genetic improvement of extensively managed beef cattle. A genome-wide association study (GWAS) was conducted to investigate genes and genetic markers associated with the outcome (pregnant or not 30 pregnant) of FTAI in 614 commercial Brahman heifers genotyped for 18,895 single nucleotide polymorphisms (SNP) and imputed to 51,588 SNP. The likelihood of Brahman heifers becoming pregnant after hormonal treatment to synchronise ovulation followed by FTAI was influenced by the Bos indicus content of their genomes, as determined by a principal component analysis (PCA). The PCA involved comparisons between the studied heifers and populations of known Bos taurus and Bos indicus ancestry. The heritability of FTAI outcome was h2 = 0.18, which is higher than for most other reproductive outcome traits. The number of SNP associated with FTAI outcome was 101 (P < 0.001, FDR = 0.53). Compared to all SNP tested, associated SNP had a tendency for highly divergent allelic frequencies between Bos indicus and Bos taurus. Associated SNP were located in nearly all chromosomes, a result that shows a complex genetic architecture that is typical of highly complex traits with low heritability. Considering this and previous GWAS that examined Brahman heifer puberty and post-partum anoestrus interval, 3 genomic regions emerge as important for overall Brahman heifer fertility, which mapped to chromosomes 1, 7 and 9. Further analyses, including improved genome annotation, are required to elucidate the link between these regions and heifer fertility. Additional studies are needed to confirm SNP and gene associations reported herein and further elucidate the genetics of FTAI outcome. Future GWAS should target other Braham populations and additional cattle breeds with FTAI records, including breeds with higher Bos taurus ancestry.
Keyword Reproductive technology
Bos indicus
Genome-wide association studies
Pregnancy outcome
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Chemistry and Molecular Biosciences
School of Veterinary Science Publications
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Citation counts: TR Web of Science Citation Count  Cited 2 times in Thomson Reuters Web of Science Article | Citations
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Created: Fri, 28 Aug 2015, 00:06:30 EST by Prycilla Rehm on behalf of School of Chemistry & Molecular Biosciences