Cardiovascular risk factor associations in adults with psychosis and adults in a national comparator sample

Foley, Debra L., Mackinnon, Andrew, Morgan, Vera A., Watts, Gerald F., Shaw, Jonathan E., Magliano, Dianna J., Castle, David J., McGrath, John J., Waterreus, Anna and Galletly, Cherrie A. (2015) Cardiovascular risk factor associations in adults with psychosis and adults in a national comparator sample. Australian and New Zealand Journal of Psychiatry, 49 8: 714-723. doi:10.1177/0004867414565476


Author Foley, Debra L.
Mackinnon, Andrew
Morgan, Vera A.
Watts, Gerald F.
Shaw, Jonathan E.
Magliano, Dianna J.
Castle, David J.
McGrath, John J.
Waterreus, Anna
Galletly, Cherrie A.
Title Cardiovascular risk factor associations in adults with psychosis and adults in a national comparator sample
Journal name Australian and New Zealand Journal of Psychiatry   Check publisher's open access policy
ISSN 1440-1614
0004-8674
Publication date 2015-08-01
Year available 2015
Sub-type Article (original research)
DOI 10.1177/0004867414565476
Open Access Status Not yet assessed
Volume 49
Issue 8
Start page 714
End page 723
Total pages 10
Place of publication London, United Kingdom
Publisher Sage Publications
Language eng
Abstract Objective: Antipsychotic drug treatment alters status on key risk factors for cardiovascular disease. The aim of this study was to test whether cardiovascular risk factor associations differ in adults with psychosis and adults from the general community.
Formatted abstract
Objective: Antipsychotic drug treatment alters status on key risk factors for cardiovascular disease. The aim of this study was to test whether cardiovascular risk factor associations differ in adults with psychosis and adults from the general community.

Method: Data were analysed for those aged 25–64 years from a nationally representative psychosis sample (n = 1,457) and a national comparator sample (n = 8,866). The Pearson correlation coefficient was used to estimate the association among tobacco use, body mass index, waist circumference, diastolic and systolic blood pressure and fasting total-, LDL- and HDL-cholesterol, triglycerides and plasma glucose. The robust Levene test was used to test for sample differences in variance.

Results: Correlations among cardiovascular risk indicators and between cardiovascular risk indicators and age were often significantly weaker in those with psychosis than in those from the national comparator sample. This was not due to a reduction in variance within the psychosis sample.

Conclusions: Risk prediction that synthesizes multivariate risk indicator data needs to be connected to verified cardiovascular morbidity and mortality in those with psychosis to determine if standard risk calculators adequately discriminate those at high, medium and low future risk of cardiovascular morbidity and mortality. Until then the clinical implications of low or absent correlations among cardiovascular risk indicators and their low or absent association with increasing age is unclear but may indicate that risk equations commonly used in the general population may not be applicable for those with treated psychosis.
Keyword Association
Cardiovascular diseases
Psychotic disorders
Risk factors
Schizophrenia
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID APP1056929
APP526609
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2016 Collection
School of Medicine Publications
 
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