Reference values for local arterial stiffness. Part B: femoral artery

Bossuyt, Jelle, Engelen, Lian, Ferreira, Isabel, Stehouwer, Coen D., Boutouyrie, Pierre, Laurent, Stephane, Segers, Patrick, Reesink, Koen, van Bortel, Luc M. and on behalf of the Reference Values for Arterial Measurements Collaboration (2015) Reference values for local arterial stiffness. Part B: femoral artery. Journal of Hypertension, 33 10: 1997-2009. doi:10.1097/HJH.0000000000000655

Author Bossuyt, Jelle
Engelen, Lian
Ferreira, Isabel
Stehouwer, Coen D.
Boutouyrie, Pierre
Laurent, Stephane
Segers, Patrick
Reesink, Koen
van Bortel, Luc M.
on behalf of the Reference Values for Arterial Measurements Collaboration
Title Reference values for local arterial stiffness. Part B: femoral artery
Journal name Journal of Hypertension   Check publisher's open access policy
ISSN 0263-6352
Publication date 2015-01-01
Year available 2015
Sub-type Article (original research)
DOI 10.1097/HJH.0000000000000655
Open Access Status Not yet assessed
Volume 33
Issue 10
Start page 1997
End page 2009
Total pages 13
Place of publication London, United Kingdom
Publisher Lippincott Williams & Wilkins
Language eng
Formatted abstract
Objective: Carotid-femoral pulse wave velocity (PWV) is considered the gold standard measure of arterial stiffness, representing mainly aortic stiffness. As compared with the elastic carotid and aorta, the more muscular femoral artery may be differently associated with cardiovascular risk factors (CV-RFs), or, as shown in a recent study, provide additional predictive information beyond carotid-femoral PWV. Still, clinical application is hampered by the absence of reference values. Therefore, our aim was to establish age and sex-specific reference values for femoral stiffness in healthy individuals and to investigate the associations with CV-RFs.

Methods: Femoral artery distensibility coefficient, the inverse of stiffness, was calculated as the ratio of relative diastolic-systolic distension (obtained from ultrasound echo-tracking) and pulse pressure among 5069 individuals (49.5% men, age range: 15–87 years). Individuals without cardiovascular disease (CVD), CV-RFs and medication use (n ¼ 1489; 43% men) constituted a healthy subpopulation used to establish sex-specific equations for percentiles of femoral artery distensibility coefficient across age.

Results: In the total population, femoral artery distensibility coefficient Z-scores were independently associated with BMI, mean arterial pressure (MAP) and total to high-density lipoprotein (HDL) cholesterol ratio. Standardized bs, in men and women, respectively, were 0.18 [95% confidence interval (95% CI) 0.23 to 0.13] and 0.19 (0.23 to 0.14) for BMI; 0.13 (0.18 to 0.08) and 0.05 (0.10 to 0.01) for MAP; and 0.07 (0.11 to 0.02) and 0.16 (0.20 to 0.11) for total-to-HDL cholesterol ratio.

Conclusion: In young and middle-aged men and women, normal femoral artery stiffness does not change substantially with age up to the sixth decade. CV-RFs related to metabolic disease are associated with femoral artery stiffness.
Keyword Ageing
Arterial stiffness
Femoral artery
Reference values
Risk factors
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID G.0131.09N
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
School of Public Health Publications
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Citation counts: TR Web of Science Citation Count  Cited 13 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 14 times in Scopus Article | Citations
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Created: Wed, 12 Aug 2015, 10:08:14 EST by Isabel Ferreira on behalf of School of Public Health