Reference values for local arterial stiffness. Part A: carotid artery

Engelen, Lian, Bossuyt, Jelle, Ferreira, Isabel, van Bortel, Luc M., Reesink, Koen, Segers, Patrick, Stehouwer, Coen D., Laurent, Stephane, Boutourie, Pierre and on behalf of the Reference Values for Arterial Measurements Collaboration (2015) Reference values for local arterial stiffness. Part A: carotid artery. Journal of Hypertension, 33 10: 1981-1996. doi:10.1097/HJH.0000000000000654

Author Engelen, Lian
Bossuyt, Jelle
Ferreira, Isabel
van Bortel, Luc M.
Reesink, Koen
Segers, Patrick
Stehouwer, Coen D.
Laurent, Stephane
Boutourie, Pierre
on behalf of the Reference Values for Arterial Measurements Collaboration
Title Reference values for local arterial stiffness. Part A: carotid artery
Journal name Journal of Hypertension   Check publisher's open access policy
ISSN 0263-6352
Publication date 2015-01-01
Year available 2015
Sub-type Article (original research)
DOI 10.1097/HJH.0000000000000654
Open Access Status Not yet assessed
Volume 33
Issue 10
Start page 1981
End page 1996
Total pages 16
Place of publication London, United Kingdom
Publisher Lippincott Williams & Wilkins
Language eng
Formatted abstract
Objective: Non-invasive measures of common carotid artery properties, such as diameter and distension, and pulse pressure, have been widely used to determine carotid artery distensibility coefficient – a measure of carotid stiffness (stiffness 1/distensibility coefficient). Carotid stiffness has been associated with incident cardiovascular disease (CVD) and may therefore be a useful intermediate marker for CVD. We aimed to establish age and sex-specific reference intervals of carotid stiffness.

Methods: We combined data on 22 708 individuals (age range 15–99 years, 54% men) from 24 research centres worldwide. Individuals without CVD and established cardiovascular risk factors constituted a healthy subpopulation (n ¼ 3601, 48% men) and were used to establish sex-specific equations for percentiles of carotid distensibility coefficient across age.

Results: In the sub-population without CVD and treatment (n ¼ 12 906, 52% men), carotid distensibility coefficient Z-scores based on these percentile equations were independently and negatively associated, in men and women, respectively, with diabetes {0.28 [95% confidence interval (CI) 0.41; 0.15] and 0.27 (0.43; 0.12)}, mean arterial pressure [0.26 (0.29; 0.24)
and 0.32 (0.35; 0.29)], total-to-high-density lipoprotein cholesterol ratio [0.05 (0.09; 0.02) and 0.05 (0.11; 0.01)] and BMI [0.06 (0.09; 0.04) and 0.05 (0.08; 0.02)], whereas these were positively associated with smoking [0.30 (0.24; 0.36) and 0.24 (0.18; 0.31)].

Conclusions: We estimated age and sex-specific percentiles of carotid stiffness in a healthy population and assessed the association between cardiovascular risk factors and carotid distensibility coefficient Z-scores, which enables comparison of carotid stiffness values between (patient) groups with different cardiovascular risk profiles, helping interpretation of such measures.
Keyword Ageing
Arterial stiffness
Carotid artery
Reference intervals
Risk factors
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
School of Public Health Publications
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Citation counts: TR Web of Science Citation Count  Cited 28 times in Thomson Reuters Web of Science Article | Citations
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Created: Wed, 12 Aug 2015, 10:02:22 EST by Isabel Ferreira on behalf of School of Public Health