Autophagy is required for stem cell mobilization by G-CSF

Leveque-El Mouttie, Lucie, Vu, Therese, Lineburg, Katie E., Kuns, Rachel D., Bagger, Frederik O., Teal, Bianca E., Lor, Mary, Boyle, Glen M., Bruedigam, Claudia, Mintern, Justine D., Hill, Geoffrey R., MacDonald, Kelli P. A. and Lane, Steven W. (2015) Autophagy is required for stem cell mobilization by G-CSF. Blood, 125 19: 2933-2936. doi:10.1182/blood-2014-03-562660

Author Leveque-El Mouttie, Lucie
Vu, Therese
Lineburg, Katie E.
Kuns, Rachel D.
Bagger, Frederik O.
Teal, Bianca E.
Lor, Mary
Boyle, Glen M.
Bruedigam, Claudia
Mintern, Justine D.
Hill, Geoffrey R.
MacDonald, Kelli P. A.
Lane, Steven W.
Title Autophagy is required for stem cell mobilization by G-CSF
Journal name Blood   Check publisher's open access policy
ISSN 1528-0020
Publication date 2015-05-07
Year available 2015
Sub-type Article (original research)
DOI 10.1182/blood-2014-03-562660
Open Access Status DOI
Volume 125
Issue 19
Start page 2933
End page 2936
Total pages 4
Place of publication Washington, United States
Publisher American Society of Hematology
Language eng
Abstract Granulocyte colony-stimulating factor (G-CSF) is widely used clinically to prevent neutropenia after cytotoxic chemotherapy and to mobilize hematopoietic stem cells (HSCs) for transplantation. Autophagy, a process of cytoplasmic component recycling, maintains cellular homeostasis and protects the cell during periods of metabolic stress or nutrient deprivation. We have observed that G-CSF activates autophagy in neutrophils and HSCs from both mouse and human donors. Furthermore, G-CSF–induced neutrophil and HSC mobilization is impaired in the absence of autophagy. In contrast, autophagy is dispensable for direct HSC mobilization in response to the CXCR4 antagonist AMD3100. Altogether, these data demonstrate an important role for G-CSF in invoking autophagy within hematopoietic and myeloid cells and suggest that this pathway is critical for ensuring cell survival in response to clinically relevant cytokine-induced stress. These findings have direct relevance to HSC transplantation and the increasing clinical use of agents that modulate autophagy.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Medicine Publications
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