Role of fitness in the metabolically healthy but obese phenotype: a review and update

Ortega, Francisco B., Cadenas-Sanchez, Cristina, Sui, Xuemei, Blair, Steven N. and Lavie, Carl J. (2015) Role of fitness in the metabolically healthy but obese phenotype: a review and update. Progress in Cardiovascular Diseases, 58 1: 76-86. doi:10.1016/j.pcad.2015.05.001

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Author Ortega, Francisco B.
Cadenas-Sanchez, Cristina
Sui, Xuemei
Blair, Steven N.
Lavie, Carl J.
Title Role of fitness in the metabolically healthy but obese phenotype: a review and update
Journal name Progress in Cardiovascular Diseases   Check publisher's open access policy
ISSN 1873-1740
Publication date 2015-07-01
Year available 2015
Sub-type Article (original research)
DOI 10.1016/j.pcad.2015.05.001
Open Access Status File (Author Post-print)
Volume 58
Issue 1
Start page 76
End page 86
Total pages 11
Publisher W.B. Saunders
Language eng
Abstract Despite the strong and consistent evidence supporting that a high physical fitness (PF) level at any age is a major predictor of a healthier metabolic profile, major studies focused on the metabolically healthy but obese (MHO) phenotype have ignored the role of PF when examining this phenotype and its prognosis. Particularly, the role of its main health-related components such as higher cardiorespiratory fitness (CRF) and muscular fitness in the MHO phenotype needs to be reviewed in depth. The present review aimed to: 1) contribute to the characterization of the MHO phenotype by examining whether MHO individuals are fitter than metabolically abnormal obese (MAO) individuals in terms of CRF and other PF components; 2) review the role of CRF and other PF components in the prognosis of MHO. The studies reviewed suggest that a higher CRF level should be considered a characteristic of the MHO phenotype. Likewise, CRF seems to play a key role in the prognosis of the MHO individuals, yet this statement is based on a single study and future studies need to confirm or contrast these findings. Comparability of studies is difficult due to the different definitions used for MHO; consequently, the present review makes a proposal for harmonizing this definition in adults and in youth. Obesity is still related to an important number of comorbidities; therefore, the public health message remains to fight against both obesity and low CRF in both adult and pediatric populations.
Keyword Cardiorespiratory fitness
Metabolically abnormal obese
Metabolically healthy but obese
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID BES-2014-068829
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Medicine Publications
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