Calcium-activated potassium currents in mammalian neurons

Sah, P and Davies, P (2000) Calcium-activated potassium currents in mammalian neurons. Clinical And Experimental Pharmacology And Physiology, 27 9: 657-663. doi:10.1046/j.1440-1681.2000.03317.x

Author Sah, P
Davies, P
Title Calcium-activated potassium currents in mammalian neurons
Journal name Clinical And Experimental Pharmacology And Physiology   Check publisher's open access policy
ISSN 0305-1870
Publication date 2000-01-01
Year available 2000
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1046/j.1440-1681.2000.03317.x
Open Access Status Not yet assessed
Volume 27
Issue 9
Start page 657
End page 663
Total pages 7
Place of publication CARLTON
Language eng
Abstract 1. Influx of calcium via voltage-dependent calcium channels during the action potential lends to increases in cytosolic calcium that can initiate a number of physiological processes. One of these is the activation of potassium currents on the plasmalemma. These calcium-activated potassium currents contribute to action potential repolarization and are largely responsible for the phenomenon of spike frequency adaptation. This refers to the progressive slowing of the frequency of discharge of action potentials during sustained injection of depolarizing current. In some cell types, this adaptation is so marked that despite the presence of depolarizing current, only a single spike (or a few spikes) is initiated, Following cessation of current injection, slow deactivation of calcium-activated potassium currents is also responsible for the prolonged hyperpolarization that often follows, 2. A number of macroscopic calcium-activated potassium currents that can be separated on the basis of kinetic and pharmacological criteria have been described in mammalian neurons. At the single channel level, several types of calcium-activated potassium channels also have been characterized. While for some macroscopic currents the underlying:single channels have been unambiguously defined, for other currents the identity of the underlying channels is not clear. 3. In the present review we describe the properties of the known types of calcium-activated potassium currents in mammalian neurons and indicate the relationship between macroscopic currents and particular single channels.
Keyword Pharmacology & Pharmacy
Small Conductance K+ Channel
Ca2+-activated K+ Current
Sympathetic-ganglion Cells
Cat Sensorimotor Cortex
Pig Vagal Motoneurons
Ca2+ Channels
Pyramidal Neurons
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: Queensland Brain Institute Publications
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Citation counts: TR Web of Science Citation Count  Cited 82 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 83 times in Scopus Article | Citations
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Created: Mon, 13 Aug 2007, 21:56:18 EST