IL-12 and IL-23 cytokines: from discovery to targeted therapies for immune-mediated inflammatory diseases

Teng, Michele W. L., Bowman, Edward P., McElwee, Joshua J., Smyth, Mark J., Casanova, Jean-Laurent, Cooper, Andrea M. and Cua, Daniel J. (2015) IL-12 and IL-23 cytokines: from discovery to targeted therapies for immune-mediated inflammatory diseases. Nature Medicine, 21 7: 719-729. doi:10.1038/nm.3895


Author Teng, Michele W. L.
Bowman, Edward P.
McElwee, Joshua J.
Smyth, Mark J.
Casanova, Jean-Laurent
Cooper, Andrea M.
Cua, Daniel J.
Title IL-12 and IL-23 cytokines: from discovery to targeted therapies for immune-mediated inflammatory diseases
Journal name Nature Medicine   Check publisher's open access policy
ISSN 1546-170X
1078-8956
Publication date 2015-07-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1038/nm.3895
Open Access Status Not yet assessed
Volume 21
Issue 7
Start page 719
End page 729
Total pages 11
Place of publication New York, United States
Publisher Nature Publishing Group
Language eng
Subject 1300 Biochemistry, Genetics and Molecular Biology
Abstract The cytokine interleukin-12 (IL-12) was thought to have a central role in T cell–mediated responses in inflammation for more than a decade after it was first identified. Discovery of the cytokine IL-23, which shares a common p40 subunit with IL-12, prompted efforts to clarify the relative contribution of these two cytokines in immune regulation. Ustekinumab, a therapeutic agent targeting both cytokines, was recently approved to treat psoriasis and psoriatic arthritis, and related agents are in clinical testing for a variety of inflammatory disorders. Here we discuss the therapeutic rationale for targeting these cytokines, the unintended consequences for host defense and tumor surveillance and potential ways in which these therapies can be applied to treat additional immune disorders.
Keyword Cytokines
Immune regulation
Ustekinumab
Arthritis
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2016 Collection
School of Medicine Publications
 
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