Type I interferons in anticancer immunity

Zitvogel, Laurence, Galluzzi, Lorenzo, Kepp, Oliver, Smyth, Mark J. and Kroemer, Guido (2015) Type I interferons in anticancer immunity. Nature Reviews Immunology, 15 7: 405-414. doi:10.1038/nri3845

Author Zitvogel, Laurence
Galluzzi, Lorenzo
Kepp, Oliver
Smyth, Mark J.
Kroemer, Guido
Title Type I interferons in anticancer immunity
Journal name Nature Reviews Immunology   Check publisher's open access policy
ISSN 1474-1741
Publication date 2015-07-26
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1038/nri3845
Open Access Status Not yet assessed
Volume 15
Issue 7
Start page 405
End page 414
Total pages 10
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Language eng
Subject 2403 Immunology
Abstract Type I interferons (IFNs) are known for their key role in antiviral immune responses. In this Review, we discuss accumulating evidence indicating that type I IFNs produced by malignant cells or tumour-infiltrating dendritic cells also control the autocrine or paracrine circuits that underlie cancer immunosurveillance. Many conventional chemotherapeutics, targeted anticancer agents, immunological adjuvants and oncolytic viruses are only fully efficient in the presence of intact type I IFN signalling. Moreover, the intratumoural expression levels of type I IFNs or of IFN-stimulated genes correlate with favourable disease outcome in several cohorts of patients with cancer. Finally, new anticancer immunotherapies are being developed that are based on recombinant type I IFNs, type I IFN-encoding vectors and type I IFN-expressing cells.
Keyword Chronic myelogenous leukemia
Plasmacytoid dendritic cell
Satge-III melanoma
Regulatory T-cells
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2016 Collection
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 159 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 161 times in Scopus Article | Citations
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