Seasonal effects on gene expression

Goldinger, Anita, Shakhbazov, Konstantin, Henders, Anjali K., McRae, Allan F., Montgomery, Grant W. and Powell, Joseph E. (2015) Seasonal effects on gene expression. PLoS ONE, 10 5: 1-16. doi:10.1371/journal.pone.0126995

Author Goldinger, Anita
Shakhbazov, Konstantin
Henders, Anjali K.
McRae, Allan F.
Montgomery, Grant W.
Powell, Joseph E.
Title Seasonal effects on gene expression
Journal name PLoS ONE   Check publisher's open access policy
ISSN 1932-6203
Publication date 2015-05-29
Year available 2015
Sub-type Article (original research)
DOI 10.1371/journal.pone.0126995
Open Access Status DOI
Volume 10
Issue 5
Start page 1
End page 16
Total pages 16
Place of publication San Francisco, CA United States
Publisher Public Library of Science
Language eng
Subject 2700 Medicine
1300 Biochemistry, Genetics and Molecular Biology
1100 Agricultural and Biological Sciences
Abstract Many health conditions, ranging from psychiatric disorders to cardiovascular disease, display notable seasonal variation in severity and onset. In order to understand the molecular processes underlying this phenomenon, we have examined seasonal variation in the transcriptome of 606 healthy individuals. We show that 74 transcripts associated with a 12-month seasonal cycle were enriched for processes involved in DNA repair and binding. An additional 94 transcripts demonstrated significant seasonal variability that was largely influenced by blood cell count levels. These transcripts were enriched for immune function, protein production, and specific cellular markers for lymphocytes. Accordingly, cell counts for erythrocytes, platelets, neutrophils, monocytes, and CD19 cells demonstrated significant association with a 12-month seasonal cycle. These results demonstrate that seasonal variation is an important environmental regulator of gene expression and blood cell composition. Notable changes in leukocyte counts and genes involved in immune function indicate that immune cell physiology varies throughout the year in healthy individuals.
Keyword Multidisciplinary Sciences
Science & Technology - Other Topics
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID 389892
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2016 Collection
UQ Diamantina Institute Publications
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Citation counts: TR Web of Science Citation Count  Cited 3 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 4 times in Scopus Article | Citations
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Created: Sat, 18 Jul 2015, 02:21:45 EST by Susan Day on behalf of UQ Diamantina Institute