Modulation of tissue fatty acids by L-carnitine attenuates metabolic syndrome in diet-induced obese rats

Panchal, Sunil K., Poudyal, Hemant, Ward, Leigh C., Waanders, Jennifer and Brown, Lindsay (2015) Modulation of tissue fatty acids by L-carnitine attenuates metabolic syndrome in diet-induced obese rats. Food and Function, 6 8: 2496-2506. doi:10.1039/C5FO00480B


Author Panchal, Sunil K.
Poudyal, Hemant
Ward, Leigh C.
Waanders, Jennifer
Brown, Lindsay
Title Modulation of tissue fatty acids by L-carnitine attenuates metabolic syndrome in diet-induced obese rats
Journal name Food and Function   Check publisher's open access policy
ISSN 2042-6496
2042-650X
Publication date 2015-07-10
Year available 2015
Sub-type Article (original research)
DOI 10.1039/C5FO00480B
Open Access Status Not Open Access
Volume 6
Issue 8
Start page 2496
End page 2506
Total pages 11
Place of publication Cambridge, United Kingdom
Publisher Royal Society of Chemistry
Language eng
Formatted abstract
Obesity and dyslipidaemia are metabolic defects resulting from impaired lipid metabolism. These impairments are associated with the development of cardiovascular disease and non-alcoholic fatty liver disease. Correcting the defects in lipid metabolism may attenuate obesity and dyslipidaemia, and reduce cardiovascular risk and liver damage. L-Carnitine supplementation was used in this study to enhance fatty acid oxidation so as to ameliorate diet-induced disturbances in lipid metabolism. Male Wistar rats (8–9 weeks old) were fed with either corn starch or high-carbohydrate, high-fat diets for 16 weeks. Separate groups were supplemented with L-carnitine (1.2% in food) on either diet for the last 8 weeks of the protocol. High-carbohydrate, high-fat diet-fed rats showed central obesity, dyslipidaemia, hypertension, impaired glucose tolerance, hyperinsulinaemia, cardiovascular remodelling and non-alcoholic fatty liver disease. L-Carnitine supplementation attenuated these high-carbohydrate, high-fat diet-induced changes, together with modifications in lipid metabolism including the inhibition of stearoyl-CoA desaturase-1 activity, reduced storage of short-chain monounsaturated fatty acids in the tissues with decreased linoleic acid content and trans fatty acids stored in retroperitoneal fat. Thus, L-carnitine supplementation attenuated the signs of metabolic syndrome through inhibition of stearoyl-CoA desaturase-1 activity, preferential β-oxidation of some fatty acids and increased storage of saturated fatty acids and relatively inert oleic acid in the tissues.
Keyword Metabolism
Fatty acids
L Carnitine
Obesity
Cardiovascular remodelling
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: School of Agriculture and Food Sciences
Official 2016 Collection
School of Chemistry and Molecular Biosciences
 
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Created: Fri, 17 Jul 2015, 19:29:40 EST by Mrs Louise Nimwegen on behalf of School of Chemistry & Molecular Biosciences