Differential gene expression in human abdominal aortic aneurysm and aortic occlusive disease

Biros, Erik, Gäbel, Gabor, Moran, Corey S., Schreurs, Charlotte, Lindeman, Jan H. N., Walker, Philip J., Nataatmadja, Maria, West, Malcolm, Holdt, Lesca M., Hinterseher, Irene, Pilarsky, Christian and Golledge, Jonathan (2015) Differential gene expression in human abdominal aortic aneurysm and aortic occlusive disease. Oncotarget, 6 15: 12984-12996.

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Author Biros, Erik
Gäbel, Gabor
Moran, Corey S.
Schreurs, Charlotte
Lindeman, Jan H. N.
Walker, Philip J.
Nataatmadja, Maria
West, Malcolm
Holdt, Lesca M.
Hinterseher, Irene
Pilarsky, Christian
Golledge, Jonathan
Title Differential gene expression in human abdominal aortic aneurysm and aortic occlusive disease
Journal name Oncotarget   Check publisher's open access policy
ISSN 1949-2553
Publication date 2015-05-01
Year available 2015
Sub-type Article (original research)
Open Access Status File (Publisher version)
Volume 6
Issue 15
Start page 12984
End page 12996
Total pages 13
Place of publication Albany, NY, United States
Publisher Impact Journals
Language eng
Formatted abstract
Abdominal aortic aneurysm (AAA) and aortic occlusive disease (AOD) represent common causes of morbidity and mortality in elderly populations which were previously believed to have common aetiologies. The aim of this study was to assess the gene expression in human AAA and AOD. We performed microarrays using aortic specimen obtained from 20 patients with small AAAs (≤ 55mm), 29 patients with large AAAs (> 55mm), 9 AOD patients, and 10 control aortic specimens obtained from organ donors. Some differentially expressed genes were validated by quantitative-PCR (qRT-PCR)/immunohistochemistry. We identified 840 and 1,014 differentially expressed genes in small and large AAAs, respectively. Immune-related pathways including cytokine-cytokine receptor interaction and T-cell-receptor signalling were upregulated in both small and large AAAs. Examples of validated genes included CTLA4 (2.01-fold upregulated in small AAA, P = 0.002), NKTR (2.37-and 2.66-fold upregulated in small and large AAA with P = 0.041 and P = 0.015, respectively), and CD8A (2.57-fold upregulated in large AAA, P = 0.004). 1,765 differentially expressed genes were identified in AOD. Pathways upregulated in AOD included metabolic and oxidative phosphorylation categories. The UCP2 gene was downregulated in AOD (3.73-fold downregulated, validated P = 0.017). In conclusion, the AAA and AOD transcriptomes were very different suggesting that AAA and AOD have distinct pathogenic mechanisms.
Keyword Abdominal
Aortic aneurysm
Arterial occlusive diseases
Tissue array analysis
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID 1020955
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 7 times in Thomson Reuters Web of Science Article | Citations
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