Inhibition of transmitter release and long-term depression in the avian hippocampus

Margrie, TW, Rostas, JAP and Sah, P (2000) Inhibition of transmitter release and long-term depression in the avian hippocampus. Neuroscience Letters, 284 1-2: 17-20. doi:10.1016/S0304-3940(00)00992-7


Author Margrie, TW
Rostas, JAP
Sah, P
Title Inhibition of transmitter release and long-term depression in the avian hippocampus
Journal name Neuroscience Letters   Check publisher's open access policy
ISSN 0304-3940
Publication date 2000-01-01
Sub-type Article (original research)
DOI 10.1016/S0304-3940(00)00992-7
Volume 284
Issue 1-2
Start page 17
End page 20
Total pages 4
Language eng
Abstract Long-term depression has recently been shown to occur at glutamatergic synapses in the avian hippocampus and requires activation of calcium/calmodulin-dependent protein kinase II in the nerve terminal. Here using whole cell and intracellular recordings from brain slices, we show that the N-type calcium channel contributes significantly to glutamate release in the avian hippocampus. Activation of the metabotrobic gamma-aminobutyric acid (GABA)(B) receptor by the specific agonist baclofen blocks synaptic transmission. The action of baclofen was associated with a change in paired pulse facilitation indicating that it resulted from a reduction in the probability of transmitter release, In contrast, no change in paired pulse facilitation was observed following the induction of long-term depression. These results show that activation of GABA(B) receptors and long-term depression reduce transmitter release by distinct mechanisms. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
Keyword Neurosciences
Long-term Depression
Transmitter Release
Protein Kinase
Gamma-aminobutyric Acids
Protein-interaction Site
Calcium Channels
Synaptic Transmission
Potentiation
Plasticity
Pigeons
Birds
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Queensland Brain Institute Publications
 
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Created: Mon, 13 Aug 2007, 21:45:00 EST