Treating rheumatoid arthritis to target: 2014 update of the recommendations of an international task force

Smolen, Josef S., Breedveld, Ferdinand C., Burmester, Gerd R., Bykerk, Vivian, Dougados, Maxime, Emery, Paul, Kvien, Tore K., Navarro-Compan, M. Victoria, Oliver, Susan, Schoels, Monika, Scholte-Voshaar, Marieke, Stamm, Tanja, Stoffer, Michaela, Takeuchi, Tsutomu, Aletaha, Daniel, Andreu, Jose Louis, Aringer, Martin, Bergman, Martin, Betteridge, Neil, Bijlsma, Hans, Burkhardt, Harald, Cardiel, Mario, Combe, Bernard, Durez, Patrick, Fonseca, Joao Eurico, Gibofsky, Alan, Gomez-Reino, Juan J., Graninger, Winfried, Hannonen, Pekka, Haraoui, Boulos, Kouloumas, Marios, Landewe, Robert, Martin-Mola, Emilio, Nash, Peter, Ostergaard, Mikkel, Östör, Andrew, Richards, Pam, Sokka-Isler, Tuulikki, Thorne, Carter, Tzioufas, Athanasios G., van Vollenhoven, Ronald, de Wit, Martinus and van der Heijde, Desirée (2015) Treating rheumatoid arthritis to target: 2014 update of the recommendations of an international task force. British Journal of Sports Medicine, 75 1: . doi:10.1136/annrheumdis-2015-207524

Author Smolen, Josef S.
Breedveld, Ferdinand C.
Burmester, Gerd R.
Bykerk, Vivian
Dougados, Maxime
Emery, Paul
Kvien, Tore K.
Navarro-Compan, M. Victoria
Oliver, Susan
Schoels, Monika
Scholte-Voshaar, Marieke
Stamm, Tanja
Stoffer, Michaela
Takeuchi, Tsutomu
Aletaha, Daniel
Andreu, Jose Louis
Aringer, Martin
Bergman, Martin
Betteridge, Neil
Bijlsma, Hans
Burkhardt, Harald
Cardiel, Mario
Combe, Bernard
Durez, Patrick
Fonseca, Joao Eurico
Gibofsky, Alan
Gomez-Reino, Juan J.
Graninger, Winfried
Hannonen, Pekka
Haraoui, Boulos
Kouloumas, Marios
Landewe, Robert
Martin-Mola, Emilio
Nash, Peter
Ostergaard, Mikkel
Östör, Andrew
Richards, Pam
Sokka-Isler, Tuulikki
Thorne, Carter
Tzioufas, Athanasios G.
van Vollenhoven, Ronald
de Wit, Martinus
van der Heijde, Desirée
Title Treating rheumatoid arthritis to target: 2014 update of the recommendations of an international task force
Journal name British Journal of Sports Medicine   Check publisher's open access policy
ISSN 0003-4967
Publication date 2015-05-12
Year available 2015
Sub-type Article (original research)
DOI 10.1136/annrheumdis-2015-207524
Open Access Status DOI
Volume 75
Issue 1
Total pages 13
Place of publication London, United Kingdom
Publisher BMJ Group
Language eng
Formatted abstract
Background: Reaching the therapeutic target of remission or low-disease activity has improved outcomes in patients with rheumatoid arthritis (RA) significantly. The treat-to-target recommendations, formulated in 2010, have provided a basis for implementation of a strategic approach towards this therapeutic goal in routine clinical practice, but these recommendations need to be re-evaluated for appropriateness and practicability in the light of new insights.

Objective: To update the 2010 treat-to-target recommendations based on systematic literature reviews (SLR) and expert opinion.

Methods: A task force of rheumatologists, patients and a nurse specialist assessed the SLR results and evaluated the individual items of the 2010 recommendations accordingly, reformulating many of the items. These were subsequently discussed, amended and voted upon by >40 experts, including 5 patients, from various regions of the world. Levels of evidence, strengths of recommendations and levels of agreement were derived.

Results: The update resulted in 4 overarching principles and 10 recommendations. The previous recommendations were partly adapted and their order changed as deemed appropriate in terms of importance in the view of the experts. The SLR had now provided also data for the effectiveness of targeting low-disease activity or remission in established rather than only early disease. The role of comorbidities, including their potential to preclude treatment intensification, was highlighted more strongly than before. The treatment aim was again defined as remission with low-disease activity being an alternative goal especially in patients with long-standing disease. Regular follow-up (every 1-3 months during active disease) with according therapeutic adaptations to reach the desired state was recommended. Follow-up examinations ought to employ composite measures of disease activity that include joint counts. Additional items provide further details for particular aspects of the disease, especially comorbidity and shared decision-making with the patient. Levels of evidence had increased for many items compared with the 2010 recommendations, and levels of agreement were very high for most of the individual recommendations (=9/10).

Conclusions: The 4 overarching principles and 10 recommendations are based on stronger evidence than before and are supposed to inform patients, rheumatologists and other stakeholders about strategies to reach optimal outcomes of RA.
Keyword Therapeutic target
Systematic literature review
Rheumatoid arthritis (ra)
Disease modifying anti-rheumatic drug (dmard)
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Medicine Publications
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 115 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 0 times in Scopus Article
Google Scholar Search Google Scholar
Created: Tue, 23 Jun 2015, 10:24:34 EST by System User on behalf of Scholarly Communication and Digitisation Service