ID4 controls mammary stem cells and marks breast cancers with a stem cell-like phenotype

Junankar, Simon, Baker, Laura A., Roden, Daniel L., Nair, Radhika, Elsworth, Ben, Gallego-Ortega, David, Lacaze, Paul, Cazet, Aurelie, Nikolic, Iva, Teo, Wee Siang, Yang, Jessica, McFarland, Andrea, Harvey, Kate, Naylor, Matthew J., Lakhani, Sunil R., Simpson, Peter T., Raghavendra, Ashwini, Saunus, Jodi, Madore, Jason, Kaplan, Warren, Ormandy, Christopher, Millar, Ewan K. A., O'Toole, Sandra, Yun, Kyuson and Swarbrick, Alexander (2015) ID4 controls mammary stem cells and marks breast cancers with a stem cell-like phenotype. Nature Communications, 6 6548.1-6548.12. doi:10.1038/ncomms7548

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Author Junankar, Simon
Baker, Laura A.
Roden, Daniel L.
Nair, Radhika
Elsworth, Ben
Gallego-Ortega, David
Lacaze, Paul
Cazet, Aurelie
Nikolic, Iva
Teo, Wee Siang
Yang, Jessica
McFarland, Andrea
Harvey, Kate
Naylor, Matthew J.
Lakhani, Sunil R.
Simpson, Peter T.
Raghavendra, Ashwini
Saunus, Jodi
Madore, Jason
Kaplan, Warren
Ormandy, Christopher
Millar, Ewan K. A.
O'Toole, Sandra
Yun, Kyuson
Swarbrick, Alexander
Title ID4 controls mammary stem cells and marks breast cancers with a stem cell-like phenotype
Journal name Nature Communications   Check publisher's open access policy
ISSN 2041-1723
Publication date 2015-01-01
Sub-type Article (original research)
DOI 10.1038/ncomms7548
Open Access Status File (Publisher version)
Volume 6
Start page 6548.1
End page 6548.12
Total pages 12
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Collection year 2016
Language eng
Abstract Basal-like breast cancer (BLBC) is a heterogeneous disease with poor prognosis; however, its cellular origins and aetiology are poorly understood. In this study, we show that inhibitor of differentiation 4 (ID4) is a key regulator of mammary stem cell self-renewal and marks a subset of BLBC with a putative mammary basal cell of origin. Using an ID4GFP knock-in reporter mouse and single-cell transcriptomics, we show that ID4 marks a stem cell-enriched subset of the mammary basal cell population. ID4 maintains the mammary stem cell pool by suppressing key factors required for luminal differentiation. Furthermore, ID4 is specifically expressed by a subset of human BLBC that possess a very poor prognosis and a transcriptional signature similar to a mammary stem cell. These studies identify ID4 as a mammary stem cell regulator, deconvolute the heterogeneity of BLBC and link a subset of mammary stem cells to the aetiology of BLBC.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
Official 2016 Collection
School of Medicine Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 10 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 11 times in Scopus Article | Citations
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Created: Wed, 17 Jun 2015, 00:49:21 EST by Anthony Yeates on behalf of UQ Centre for Clinical Research