Clinical features and impact of myasthenia gravis disease in Australian patients

Blum, Stefan, Lee, David, Gillis, David, McEniery, David F., Reddel, Stephen and McCombe, Pamela (2015) Clinical features and impact of myasthenia gravis disease in Australian patients. Journal of Clinical Neuroscience, 22 7: 1164-1169. doi:10.1016/j.jocn.2015.01.022


Author Blum, Stefan
Lee, David
Gillis, David
McEniery, David F.
Reddel, Stephen
McCombe, Pamela
Title Clinical features and impact of myasthenia gravis disease in Australian patients
Journal name Journal of Clinical Neuroscience   Check publisher's open access policy
ISSN 1532-2653
0967-5868
Publication date 2015-07-01
Year available 2015
Sub-type Article (original research)
DOI 10.1016/j.jocn.2015.01.022
Volume 22
Issue 7
Start page 1164
End page 1169
Total pages 6
Place of publication London, United Kingdom
Publisher Churchill Livingstone
Language eng
Abstract We performed a community-based survey of 165 Australian patients with a physician-confirmed diagnosis of myasthenia gravis (MG). MG is an autoimmune disease of the neuromuscular junction causing fatiguable muscle weakness. Patients with early onset MG (<40 years of age) were more frequently female (22 males, 60 females) whereas patients with late onset MG (>40 years of age) were more frequently male (50 males, 28 females; p < 0.001). Triggering and exacerbating factors included physical and emotional stress, infections, surgery or trauma, seasonal changes and medications. The co-occurrence of other immune-related diseases was reported by 54% of patients. The median MG quality of life (QOL) score was 92 (range: 24–186). The factor most strongly associated with poor QOL was depression. Only 40.6% of patients were working at the time of the survey and of these, almost half had required sick leave due to MG in the past 12 months. A further 39.4% had stopped work due to MG and 19.4% having to change occupation. Full-time or part-time care was required by 29% of patients and government financial support was received by 52.7%.
Keyword Epidemiology
Myasthenia gravis
Quality of life
Thymectomy
Triggers
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
Official 2016 Collection
School of Medicine Publications
 
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