Immediate and delayed hypersensitivity reactions to a single dose of oxaliplatin

Grewal, Grewal D., Badrick, Timothy C. and Gilbar, Peter J. (2015) Immediate and delayed hypersensitivity reactions to a single dose of oxaliplatin. Clinical Colorectal Cancer, 14 2: 128-130. doi:10.1016/j.clcc.2014.12.010

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Author Grewal, Grewal D.
Badrick, Timothy C.
Gilbar, Peter J.
Title Immediate and delayed hypersensitivity reactions to a single dose of oxaliplatin
Journal name Clinical Colorectal Cancer   Check publisher's open access policy
ISSN 1938-0674
Publication date 2015-06-01
Sub-type Article (original research)
DOI 10.1016/j.clcc.2014.12.010
Open Access Status File (Author Post-print)
Volume 14
Issue 2
Start page 128
End page 130
Total pages 3
Place of publication New York, NY, United States
Publisher Elsevier
Language eng
Subject 2730 Oncology
2715 Gastroenterology
2700 Medicine
Formatted abstract
Clinical Practice Points

• Hypersensitivity reaction (HSR) occurring during or immediately after oxaliplatin infusions are well documented and occur more commonly after multiple courses of therapy.

• A 69-year-old white woman with stage III colon cancer commenced adjuvant chemotherapy with oxaliplatin and capecitabine. Ten minutes after the completion of the oxaliplatin infusion she experienced a severe hypersensitivity reaction. Symptoms resolved after treatment with corticosteroids, antihistamines, and bronchodilators. Nineteen hours later, a similar reaction occurred.

• A review of the literature found 2 similar cases of delayed reactions to oxaliplatin occurring 20 and 10 hours after infusion, respectively. The first case occurred after the initial dose and again with cycle 2. The second case happened after the sixth infusion.

• This is the first reported case, to our knowledge, of immediate and delayed hypersensitivity reactions occurring after the initial dose of oxaliplatin.
Keyword Bronchospasm
Hypersensitivity reaction
Initial dose
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
School of Medicine Publications
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