Beyond ovulation: Oral contraceptives and epithelial ovarian cancer

Siskind, V., Purdie, D. M., Bain, C. J. and Purdie, D (2000) Beyond ovulation: Oral contraceptives and epithelial ovarian cancer. Epidemiology, 11 2: 106-110. doi:10.1097/00001648-200003000-00005


Author Siskind, V.
Purdie, D. M.
Bain, C. J.
Purdie, D
Title Beyond ovulation: Oral contraceptives and epithelial ovarian cancer
Journal name Epidemiology   Check publisher's open access policy
ISSN 1044-3983
1531-5487
Publication date 2000-03-01
Sub-type Article (original research)
DOI 10.1097/00001648-200003000-00005
Open Access Status Not yet assessed
Volume 11
Issue 2
Start page 106
End page 110
Total pages 5
Place of publication Philadelphia
Publisher Lippincott, Williams & Wilkins
Language eng
Subject 321202 Epidemiology
730108 Cancer and related disorders
C1
Abstract In a case-control study in three Australian states that included 794 women with epithelial ovarian cancer and 853 community controls for whom we had adequate contraceptive and reproductive histories, Re examined the effects of oral contraceptive use after controlling for estimated number of ovulatory cycles. Other covariates included in the multiple logistic regression analysis were parity, smoking, and history of pelvic surgery. The protective effect of duration of oral contraceptive use appeared to be multiplicative, with a 7% decrease in relative risk per year [95% confidence interval (CI) = 4-9%], persisting beyond 15 years of exposure. Use for up to 1 year may have a greater effect than predicted (odds ratio = 0.57; 95% CI = 0.40-0.82), whereas use before the first pregnancy may be additionally beneficial (odds ratio = 0.95; 95% CI = 0.87-1.03, adjusted for overall duration of use). Better control for ovulatory life might attenuate these estimates somewhat. There was little evidence of waning protection with time since last exposure or of extra benefit with early commencement of oral contraceptive use. We found no convincing evidence of effect modification in any factor examined or differences in effect among the three main histologic cancer types or between borderline and malignant tumors. Oral contraceptives may act by both suppressing ovulation and altering the tumor-promoting milieu.
Keyword Public, Environmental & Occupational Health
Ovarian Neoplasms
Oral Contraceptives
Incessant Ovulation
Duration Of Use
Ovulatory Life
Progestins
Mutant P53
Risk
Menopause
Cycles
Women
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Public Health Publications
 
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Created: Mon, 13 Aug 2007, 21:36:59 EST