Dietary Interventions in Asthma

Scott, Hayley A., Jensen, Megan E. and Wood, Lisa G. (2014) Dietary Interventions in Asthma. Current Pharmaceutical Design, 20 6: 1003-1010. doi:10.2174/13816128113190990421

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Author Scott, Hayley A.
Jensen, Megan E.
Wood, Lisa G.
Title Dietary Interventions in Asthma
Journal name Current Pharmaceutical Design   Check publisher's open access policy
ISSN 1381-6128
1873-4286
Publication date 2014-02-01
Year available 2014
Sub-type Article (original research)
DOI 10.2174/13816128113190990421
Volume 20
Issue 6
Start page 1003
End page 1010
Total pages 8
Place of publication Bussum, The Netherlands
Publisher Bentham Science Publishers
Language eng
Formatted abstract
Asthma is a chronic inflammatory disorder of the airways. The inflammatory response in asthma is heterogeneous. Allergen specific responses lead to activation of the acquired immune system, via a predominantly IL-5 mediated, eosinophilic pathway. Stimuli such as viruses and bacteria activate the innate immune system, via a predominantly IL-8 mediated, neutrophilic pathway. Asthma has also been demonstrated to involve a systemic inflammatory component. Glucocorticoids are the predominant pharmacological treatment used to control inflammation in asthma. However, compliance with medications can be compromised due to patient concerns about side effects. Hence dietary interventions that target the inflammatory response in asthma have great potential. Various aspects of dietary intake are known to modulate inflammation. Saturated fatty acids can induce an inflammatory response via activation of pattern recognition receptors. Omega-3 fatty acids can be anti-inflammatory, via mechanisms such as modification of eicosanoid production. Antioxidants can have anti-inflammatory effects as they scavenge free radicals, preventing activation of transcription factors including NF-κB. Chronic excess energy intake can lead to obesity, which augments inflammation due to the release of inflammatory mediators by adipose tissue. Here we review the role of these dietary components in asthma
Keyword Asthma
Antioxidants
Fatty Acids
Obesity
Inflammation
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
School of Medicine Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 8 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 9 times in Scopus Article | Citations
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Created: Thu, 28 May 2015, 23:33:32 EST by Hayley Scott on behalf of Medicine - Princess Alexandra Hospital