An illustrated anatomical ontology of the developing mouse lower urogenital tract

Georgas, Kylie M., Armstrong, Jane, Keast, Janet R., Larkins, Christine E., McHugh, Kirk M., Southard-Smith, E. Michelle, Cohn, Martin J., Batourina, Ekatherina, Dan, Hanbin, Schneider, Kerry, Buehler, Dennis P., Wiese, Carrie B., Brennan, Jane, Davies, Jamie A., Harding Simon D., Baldock, Richard A., Little, Melissa H., Vezina, Chad M. and Mendelsohn, Cathy (2015) An illustrated anatomical ontology of the developing mouse lower urogenital tract. Development (Cambridge), 142 10: 1893-1908. doi:10.1242/dev.117903

Attached Files (Some files may be inaccessible until you login with your UQ eSpace credentials)
Name Description MIMEType Size Downloads
UQ360859_OA.pdf Full text (open access) application/pdf 10.16MB 0

Author Georgas, Kylie M.
Armstrong, Jane
Keast, Janet R.
Larkins, Christine E.
McHugh, Kirk M.
Southard-Smith, E. Michelle
Cohn, Martin J.
Batourina, Ekatherina
Dan, Hanbin
Schneider, Kerry
Buehler, Dennis P.
Wiese, Carrie B.
Brennan, Jane
Davies, Jamie A.
Harding Simon D.
Baldock, Richard A.
Little, Melissa H.
Vezina, Chad M.
Mendelsohn, Cathy
Title An illustrated anatomical ontology of the developing mouse lower urogenital tract
Journal name Development (Cambridge)   Check publisher's open access policy
ISSN 1477-9129
Publication date 2015-05-15
Year available 2015
Sub-type Article (original research)
DOI 10.1242/dev.117903
Open Access Status File (Publisher version)
Volume 142
Issue 10
Start page 1893
End page 1908
Total pages 15
Place of publication Cambridge, United Kingdom
Publisher The Company of Biologists
Language eng
Abstract Malformation of the urogenital tract represents a considerable paediatric burden, with many defects affecting the lower urinary tract (LUT), genital tubercle and associated structures. Understanding the molecular basis of such defects frequently draws on murine models. However, human anatomical terms do not always superimpose on the mouse, and the lack of accurate and standardised nomenclature is hampering the utility of such animal models. We previously developed an anatomical ontology for the murine urogenital system. Here, we present a comprehensive update of this ontology pertaining to mouse LUT, genital tubercle and associated reproductive structures (E10.5 to adult). Ontology changes were based on recently published insights into the cellular and gross anatomy of these structures, and on new analyses of epithelial cell types present in the pelvic urethra and regions of the bladder. Ontology changes include new structures, tissue layers and cell types within the LUT, external genitalia and lower reproductive structures. Representative illustrations, detailed text descriptions and molecular markers that selectively label muscle, nerves/ganglia and epithelia of the lower urogenital system are also presented. The revised ontology will be an important tool for researchers studying urogenital development/malformation in mouse models and will improve our capacity to appropriately interpret these with respect to the human situation.
Keyword Bladder
External genitalia
Genital tubercle
Lower reproductive tract
Lower urinary tract
Mouse embryogenesis
Murine urogenital system development
Pelvic ganglion
Pelvic urethra
Phallic urethra
Prostate gland
Urethral plate
Urogenital sinus
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID R01DK085242
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
Institute for Molecular Bioscience - Publications
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 25 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 29 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Tue, 26 May 2015, 13:11:03 EST by System User on behalf of Scholarly Communication and Digitisation Service