A ring to rule them all: the effect of cyclopropane fatty acids on the fluidity of lipid bilayers

Poger, David and Mark, Alan E. (2015) A ring to rule them all: the effect of cyclopropane fatty acids on the fluidity of lipid bilayers. Journal of Physical Chemistry B, 119 17: 5487-5495. doi:10.1021/acs.jpcb.5b00958


Author Poger, David
Mark, Alan E.
Title A ring to rule them all: the effect of cyclopropane fatty acids on the fluidity of lipid bilayers
Journal name Journal of Physical Chemistry B   Check publisher's open access policy
ISSN 1520-5207
1520-6106
Publication date 2015-04-30
Year available 2015
Sub-type Article (original research)
DOI 10.1021/acs.jpcb.5b00958
Volume 119
Issue 17
Start page 5487
End page 5495
Total pages 9
Place of publication Washington, DC, United States
Publisher American Chemical Society
Collection year 2016
Formatted abstract
Cyclopropane fatty acids are widespread in bacteria. As their concentration increases on exposure to hostile environments, they have been proposed to protect membranes. Here, the effect of cyclopropane and unsaturated fatty acids, both in cis and trans configurations, on the packing, order, and fluidity of lipid bilayers is explored using molecular dynamics simulations. It is shown that cyclopropane fatty acids disrupt lipid packing, favor the occurrence of gauche defects in the chains, and increase the lipid lateral diffusion, suggesting that they enhance fluidity. At the same time, they generally induce a greater degree of order than unsaturated fatty acids of the same configuration and limit the rotation about the bonds surrounding the cyclopropane ring. This indicates that cyclopropane fatty acids may fulfill a dual function: stabilizing membranes against adverse conditions while simultaneously promoting their fluidity. Marked differences in the effect of cis- and trans-monocyclopropanated fatty acids were also observed, suggesting that they may play alternative roles in membranes.
Keyword Fluidity
Diffusion in liquids
Lipid bilayers
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Chemistry and Molecular Biosciences
Institute for Molecular Bioscience - Publications
 
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