Is the complement activation product C3a a proinflammatory molecule? Re-evaluating the evidence and the myth

Coulthard, Liam G. and Woodruff, Trent M. (2015) Is the complement activation product C3a a proinflammatory molecule? Re-evaluating the evidence and the myth. Journal of Immunology, 194 8: 3542-3548. doi:10.4049/jimmunol.1403068


Author Coulthard, Liam G.
Woodruff, Trent M.
Title Is the complement activation product C3a a proinflammatory molecule? Re-evaluating the evidence and the myth
Journal name Journal of Immunology   Check publisher's open access policy
ISSN 1550-6606
0022-1767
Publication date 2015-04-15
Year available 2015
Sub-type Critical review of research, literature review, critical commentary
DOI 10.4049/jimmunol.1403068
Open Access Status DOI
Volume 194
Issue 8
Start page 3542
End page 3548
Total pages 7
Place of publication Bethesda, MD United States
Publisher American Association of Immunologists
Language eng
Abstract The complement activation product C3a is often described as a proinflammatory mediator, alongside its downstream cousin, C5a. However, emerging studies show that C3a has several anti-inflammatory facets in vivo. For example, in the acute inflammatory response, C3a acts in direct opposition to C5a, through preventing the accumulation of neutrophils in inflamed tissues by independently regulating their mobilization. This acute, protective, and opposing activity of C3a to C5a is also illustrated in models of septicemia. In this article, we reinvestigate the discovery and original classification of C3a as a proinflammatory mediator and highlight the emerging studies demonstrating anti-inflammatory effects for C3a in the immune response. It is our hope that this review illuminates these apparently contradictory roles for C3a and challenges the general dogma surrounding C3a, which, historically, has ubiquitously been described as a proinflammatory mediator. In light of this, we urge investigators to use “inflammatory modulator” as the descriptor for C3a.
Keyword Immunology
Immunology
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2016 Collection
School of Biomedical Sciences Publications
 
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