Cardiorespiratory fitness, physical activity, and arterial stiffness: the Northern Ireland young hearts project

Boreham, Colin A., Ferreira, Isabel, Twisk, Jos W., Gallagher, Alison M., Savage, Maurice J. and Murray, Liam J. (2004) Cardiorespiratory fitness, physical activity, and arterial stiffness: the Northern Ireland young hearts project. Hypertension, 44 5: 721-726. doi:10.1161/01.HYP.0000144293.40699.9a

Author Boreham, Colin A.
Ferreira, Isabel
Twisk, Jos W.
Gallagher, Alison M.
Savage, Maurice J.
Murray, Liam J.
Title Cardiorespiratory fitness, physical activity, and arterial stiffness: the Northern Ireland young hearts project
Journal name Hypertension   Check publisher's open access policy
ISSN 0194-911X
Publication date 2004-11-01
Sub-type Article (original research)
DOI 10.1161/01.HYP.0000144293.40699.9a
Open Access Status Not yet assessed
Volume 44
Issue 5
Start page 721
End page 726
Total pages 6
Place of publication Philadelphia, PA, United States
Publisher Lippincott Williams & Wilkins
Language eng
Abstract Poor cardiorespiratory fitness and low physical activity have been identified as determinants of greater arterial stiffness, a mechanism that can partially explain the association of both variables with increased cardiovascular disease. However, the nature of these associations are not clear because cardiorespiratory fitness and physical activity can both mediate and confound the associations of one another with arterial stiffness. This issue was therefore examined in a population-based cohort of young adults. Subjects included 405 young men and women participating in an ongoing longitudinal study, the Northern Ireland Young Hearts Project. Pulse wave velocity was used to determine arterial stiffness in 2 arterial segments (aortoiliac and aortodorsalis pedis) using a noninvasive optical method. Cardiovascular fitness was estimated with a submaximal cycle test of physical work capacity and physical activity was estimated using a modified Baecke questionnaire. Associations were investigated with the use of multiple linear regression models with adjustment for potential confounders and/or intermediate variables. Cardiorespiratory fitness and sports-related physical activity (but not leisure- and work-related physical activity) were inversely associated with arterial stiffness in young adults. The associations between sports-related physical activity and arterial stiffness were strongly mediated by cardiorespiratory fitness, whereas physical activity levels did not disturb the associations between cardiopulmonary fitness and arterial stiffness. These findings suggest that arterial stiffness-related benefits of exercise are most likely to accrue if exercise prescription in young adults targets improvements in cardiorespiratory fitness.
Keyword Arteriosclerosis
Cross-sectional studies
Hypertension, arterial
Young adults
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Public Health Publications
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Citation counts: TR Web of Science Citation Count  Cited 75 times in Thomson Reuters Web of Science Article | Citations
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Created: Thu, 21 May 2015, 07:36:03 EST by Isabel Ferreira on behalf of Learning and Research Services (UQ Library)