The association between the-374T/A polymorphism of the receptor for advanced glycation endproducts gene and blood pressure and arterial stiffness is modified by glucose metabolism status: The Hoorn and CoDAM studies

Engelen, Lian, Ferreira, Isabel, Gaens, Katrien H. J., Henry, Ronald M. A., Dekker, Jacqueline M., Nijpels, Giel, Heine, Robert J., 't Hart, Leen M., van Greevenbroek, Marleen M. J., van der Kallen, Carla J. H., Blaak, Ellen E., Feskens, Edith J. M., ten Cate, Hugo, Stehouwer, Coen D. A. and Schalkwijk, Casper G. (2010) The association between the-374T/A polymorphism of the receptor for advanced glycation endproducts gene and blood pressure and arterial stiffness is modified by glucose metabolism status: The Hoorn and CoDAM studies. Journal of Hypertension, 28 2: 285-293. doi:10.1097/HJH.0b013e3283330931


Author Engelen, Lian
Ferreira, Isabel
Gaens, Katrien H. J.
Henry, Ronald M. A.
Dekker, Jacqueline M.
Nijpels, Giel
Heine, Robert J.
't Hart, Leen M.
van Greevenbroek, Marleen M. J.
van der Kallen, Carla J. H.
Blaak, Ellen E.
Feskens, Edith J. M.
ten Cate, Hugo
Stehouwer, Coen D. A.
Schalkwijk, Casper G.
Title The association between the-374T/A polymorphism of the receptor for advanced glycation endproducts gene and blood pressure and arterial stiffness is modified by glucose metabolism status: The Hoorn and CoDAM studies
Journal name Journal of Hypertension   Check publisher's open access policy
ISSN 0263-6352
1473-5598
Publication date 2010-01-01
Year available 2010
Sub-type Article (original research)
DOI 10.1097/HJH.0b013e3283330931
Open Access Status
Volume 28
Issue 2
Start page 285
End page 293
Total pages 9
Place of publication London, United Kingdom
Publisher Lippincott Williams and Wilkins
Language eng
Abstract Objectives: Receptor for advanced glycation endproducts (RAGE)-ligand interaction may lead to vascular complications. Genetic variation in RAGE has been shown to alter expression, activity of RAGE or both. We, therefore, investigated whether RAGE single-nucleotide polymorphisms (SNPs) and haplotypes were associated with vascular disease. Methods: Nine tag SNPs that cover the common RAGE gene variation were genotyped in 1291 individuals from two Dutch population-based cohort studies, aged 64.5 ± 8.6 years, with normal glucose metabolism (44%), impaired glucose metabolism (23%) or type 2 diabetes mellitus (33%). We used multiple regression analyses to compare prevalent cardiovascular disease and markers of atherosclerosis, blood pressure and arterial stiffness across genotypes, and examine effect modification by glucose metabolism status. Results: In unstratified analyses, no consistent associations between RAGE SNPs and prevalent cardiovascular disease and markers of atherosclerosis were found. However, the AA genotype of SNP rs1800624 (-374T/A) was consistently associated with lower SBP [-5.0 mmHg (95% confidence interval-10.4 to 0.3)] and DBP [-4.2 (-7.2 to-1.3)], pulse pressure [-0.8 (-5.0 to 3.4)] as well as with less arterial stiffness [-0.56 SD (-1.04 to-0.09)] in individuals with normal glucose metabolism, but with higher SBP [6.2 (0.9-11.5)], DBP [2.1 (-0.7 to 5.0)] and pulse pressure [4.1 (-0.2 to 8.4)] in individuals with impaired glucose metabolism or type 2 diabetes mellitus (P for interaction ≤0.05 in all analyses). Similar results were found for a haplotype that includes the-374A allele. Conclusion: In individuals with normal glucose metabolism, the-374A allele of the RAGE gene is protectively associated with blood pressure and arterial stiffness, whereas in individuals with impaired glucose metabolism or type 2 diabetes mellitus, it is adversely associated with these variables.
Keyword Advanced glycation
Arterial stiffness
Atherosclerosis
Blood pressure
Cardiovascular disease
Gene polymorphisms
Glucose metabolism
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Public Health Publications
 
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Created: Thu, 21 May 2015, 02:46:27 EST by Isabel Ferreira on behalf of School of Public Health