Patients with premature cardiovascular disease and a positive family history for cardiovascular disease are prone to recurrent events

Mulders, Ties A., Meyer, Zainna, van der Donk, Christel, Kroon, Abraham A., Ferreira, Isabel, Stehouwer, Coen D. A. and Pinto-Sietsma, Sara-Joan (2011) Patients with premature cardiovascular disease and a positive family history for cardiovascular disease are prone to recurrent events. International Journal of Cardiology, 153 1: 64-67. doi:10.1016/j.ijcard.2010.08.040


Author Mulders, Ties A.
Meyer, Zainna
van der Donk, Christel
Kroon, Abraham A.
Ferreira, Isabel
Stehouwer, Coen D. A.
Pinto-Sietsma, Sara-Joan
Title Patients with premature cardiovascular disease and a positive family history for cardiovascular disease are prone to recurrent events
Journal name International Journal of Cardiology   Check publisher's open access policy
ISSN 0167-5273
1874-1754
Publication date 2011-11-17
Year available 2011
Sub-type Article (original research)
DOI 10.1016/j.ijcard.2010.08.040
Volume 153
Issue 1
Start page 64
End page 67
Total pages 4
Place of publication Shannon, Clare Ireland
Publisher Elsevier Ireland
Language eng
Abstract Background: Premature cardiovascular disease (CVD) is treated in the same way as CVD of advanced age. However, in patients with premature CVD and a family history of CVD, different -possibly genetic- mechanisms may underlie this disease, which current medical treatment is not targeted to. This suggests that subjects with a genetic predisposition to CVD are more likely to have recurrent cardiovascular events. Methods: We retrospectively investigated 291 patients with premature CVD and assessed the amount of recurrent events according to family history in a follow-up period of 31 years. Premature CVD was defined as an event < 51 years for men or < 56 for women. We used a Cox proportional hazards model to estimate the relationship between a positive family history and recurrence of cardiovascular events. Results: Patients with recurrent events had more often a positive family history (60.0% vs. 47.1%; p < 0.05), were more often smokers (85.2% vs. 70.7%; p < 0.05), had more often hypertension (36.3% vs. 23.6%; p < 0.05) and had a longer follow-up period (10.0 years vs. 5.4 years; p < 0.001) than patients without recurrent events. After adjusting for these differences and modelling time to events, a positive family history was independently associated with recurrent events (Hazard ratio 1.31 (95% confidence intervals (CI) 1.01-1.72; p < 0.05)). Conclusions: Patients with a genetic predisposition for CVD are at risk for recurrent events, after adjusting for risk factors and other confounders. This might imply that in subjects with a genetic predisposition for CVD different pathophysiological mechanisms are active, leading to recurrent events.
Keyword Positive family history
Premature cardiovascular disease
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Public Health Publications
 
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Created: Thu, 21 May 2015, 02:38:45 EST by Isabel Ferreira on behalf of School of Public Health