Diabetes and survival after coronary artery bypass grafting: comparison with an age- and sex-matched population

van Straten, Albert H. M., Hamad, Mohamed A. Soliman, van Zundert, Andre A. J., Martens, Elisabeth J., Schonberger, Jacques P. A. M., ter Woorst, Joost F. J. and de Wolf, Andre M. (2010) Diabetes and survival after coronary artery bypass grafting: comparison with an age- and sex-matched population. European Journal of Cardio-thoracic Surgery, 37 5: 1068-1074. doi:10.1016/j.ejcts.2009.11.042


Author van Straten, Albert H. M.
Hamad, Mohamed A. Soliman
van Zundert, Andre A. J.
Martens, Elisabeth J.
Schonberger, Jacques P. A. M.
ter Woorst, Joost F. J.
de Wolf, Andre M.
Title Diabetes and survival after coronary artery bypass grafting: comparison with an age- and sex-matched population
Journal name European Journal of Cardio-thoracic Surgery   Check publisher's open access policy
ISSN 1010-7940
1873-734X
Publication date 2010-01-01
Year available 2010
Sub-type Article (original research)
DOI 10.1016/j.ejcts.2009.11.042
Volume 37
Issue 5
Start page 1068
End page 1074
Total pages 7
Place of publication Oxford, United Kingdom
Publisher Oxford University Press
Language eng
Abstract Objective: Long-term outcome after coronary artery bypass grafting is worse in diabetic than in non-diabetic patients. No data are currently available regarding survival rates of diabetic and non-diabetic patients after coronary revascularisation compared with cohorts from the general population in the Netherlands, which were matched for age and sex (normal Dutch survival). Methods: We retrospectively analysed the data from 10 626 patients who underwent coronary artery bypass grafting between January 1998 and December 2007. Of these, 8287 patients were non-diabetic, 1587 were non-insulin-dependent and 630 were insulin-dependent diabetic patients (122 patients were lost to follow-up). Survival of these patient groups was compared with the normal Dutch survival. Results: Multivariate analyses revealed non-insulin-dependent diabetes to be a risk factor for early mortality and both insulin-dependent and non-insulin-dependent diabetes as risk factors for late mortality. The 1-, 5- and 10-year survival rates for non-diabetic patients were 94.1% ± 0.3%, 86.8% ± 0.4% and 75.1% ± 1.7%, respectively, which was better than the normal Dutch survival. For insulin-dependent diabetic patients, 1-, 5- and 10-year survival rates were 90.3% ± 1.2%, 78.0% ± 2.0% and 60.5% ± 4.6%, respectively, and for non-insulin-dependent diabetic patients 91.4% ± 0.7%, 79.0% ± 1.3% and 58.9% ± 3.4%, respectively, which was worse than the normal Dutch survival. Conclusions: Non-insulin-dependent diabetes was a risk factor for early mortality and both types of diabetes were risk factors for late mortality after revascularisation. Compared with age- and sex-matched cohorts from the general Dutch population, the 10-year survival of non-diabetic patients was better; whereas the survival of both types of diabetic patients was worse.
Keyword CABG
Coronary artery bypass grafting
Diabetes mellitus
Survival
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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Created: Wed, 20 May 2015, 22:08:00 EST by Andre Van Zundert on behalf of Anaesthesiology and Critical Care - RBWH