Determinants of pulse wave velocity in healthy people and in the presence of cardiovascular risk factors: establishing normal and reference values

Mattace-Raso, Francesco U. S., Hofman, Albert, Verwoert, Germaine C., Witteman, Jacqueline C. M., Wilkinson, Ian, Cockcroft, John, McEniery, Carmel, Yasmin, Laurent, Stephane, Boutouyrie, Pierre, Bozec, Erwan, Hansen, Tine Willum, Torp-Pedersen, Christian, Ibsen, Hans, Jeppesen, Jorgen, Vermeersch, Sebastian J., Rietzschel, Ernst, De Buyzere, Marc, Gillebert, Thierry C., Van Bortel, Luc, Segers, Patrick, Vlachopoulos, Charalambos, Aznaouridis, Constantinos, Stefanadis, Christodoulos, Benetos, Athanase, Labat, Carlos, Lacolley, Patrick, Stehouwer, Coen D. A., Nijpels, Giel, Dekker, Jacqueline M., Ferreira, Isabel, Twisk, Jos W. R., Czernichow, Sebastien, Galan, Pilar, Hercberg, Serge, Pannier, Bruno, Guerin, Alain, London, Gerard, Cruickshank, J. Kennedy, Anderson, Simon G., Paini, Anna, Rosei, Enrico Agabiti, Muiesan, Maria Lorenza, Salvetti, Massimo, Filipovsky, Jan, Seidlerova, Jitka and Dolejsova, Milena (2010) Determinants of pulse wave velocity in healthy people and in the presence of cardiovascular risk factors: establishing normal and reference values. European Heart Journal, 31 19: 2338-2350. doi:10.1093/eurheartj/ehq165

Author Mattace-Raso, Francesco U. S.
Hofman, Albert
Verwoert, Germaine C.
Witteman, Jacqueline C. M.
Wilkinson, Ian
Cockcroft, John
McEniery, Carmel
Laurent, Stephane
Boutouyrie, Pierre
Bozec, Erwan
Hansen, Tine Willum
Torp-Pedersen, Christian
Ibsen, Hans
Jeppesen, Jorgen
Vermeersch, Sebastian J.
Rietzschel, Ernst
De Buyzere, Marc
Gillebert, Thierry C.
Van Bortel, Luc
Segers, Patrick
Vlachopoulos, Charalambos
Aznaouridis, Constantinos
Stefanadis, Christodoulos
Benetos, Athanase
Labat, Carlos
Lacolley, Patrick
Stehouwer, Coen D. A.
Nijpels, Giel
Dekker, Jacqueline M.
Ferreira, Isabel
Twisk, Jos W. R.
Czernichow, Sebastien
Galan, Pilar
Hercberg, Serge
Pannier, Bruno
Guerin, Alain
London, Gerard
Cruickshank, J. Kennedy
Anderson, Simon G.
Paini, Anna
Rosei, Enrico Agabiti
Muiesan, Maria Lorenza
Salvetti, Massimo
Filipovsky, Jan
Seidlerova, Jitka
Dolejsova, Milena
Title Determinants of pulse wave velocity in healthy people and in the presence of cardiovascular risk factors: establishing normal and reference values
Journal name European Heart Journal   Check publisher's open access policy
ISSN 0195-668X
Publication date 2010-10-01
Year available 2010
Sub-type Article (original research)
DOI 10.1093/eurheartj/ehq165
Open Access Status DOI
Volume 31
Issue 19
Start page 2338
End page 2350
Total pages 13
Place of publication Oxford, United Kingdom
Publisher Oxford University Press
Language eng
Formatted abstract
Aims: Carotid-femoral pulse wave velocity (PWV), a direct measure of aortic stiffness, has become increasingly important for total cardiovascular (CV) risk estimation. Its application as a routine tool for clinical patient evaluation has been hampered by the absence of reference values. The aim of the present study is to establish reference and normal values for PWV based on a large European population.

Methods and results: We gathered data from 16 867 subjects and patients from 13 different centres across eight European countries, in which PWV and basic clinical parameters were measured. Of these, 11 092 individuals were free from overt CV disease, non-diabetic and untreated by either anti-hypertensive or lipid-lowering drugs and constituted the reference value population, of which the subset with optimal/normal blood pressures (BPs) (n = 1455) is the normal value population. Prior to data pooling, PWV values were converted to a common standard using established conversion formulae. Subjects were categorized by age decade and further subdivided according to BP categories. Pulse wave velocity increased with age and BP category; the increase with age being more pronounced for higher BP categories and the increase with BP being more important for older subjects. The distribution of PWV with age and BP category is described and reference values for PWV are established. Normal values are proposed based on the PWV values observed in the non-hypertensive subpopulation who had no additional CV risk factors.

Conclusion: The present study is the first to establish reference and normal values for PWV, combining a sizeable European population after standardizing results for different methods of PWV measurement.
Keyword Adult
Blood pressure
Pulse wave velocity
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID ANR-05-PCOD-004-01
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Public Health Publications
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