Arterial stiffness in diabetes and the metabolic syndrome: a pathway to cardiovascular disease

Stehouwer, C. D. A., Henry, R. M. A. and Ferreira, I. (2008) Arterial stiffness in diabetes and the metabolic syndrome: a pathway to cardiovascular disease. Diabetologia, 51 4: 527-539. doi:10.1007/s00125-007-0918-3


Author Stehouwer, C. D. A.
Henry, R. M. A.
Ferreira, I.
Title Arterial stiffness in diabetes and the metabolic syndrome: a pathway to cardiovascular disease
Journal name Diabetologia   Check publisher's open access policy
ISSN 0012-186X
1432-0428
Publication date 2008-04-01
Year available 2008
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1007/s00125-007-0918-3
Open Access Status Not yet assessed
Volume 51
Issue 4
Start page 527
End page 539
Total pages 13
Place of publication Heidelberg, Germany
Publisher Springer
Language eng
Abstract Increased arterial stiffness associated with diabetes and the metabolic syndrome may in part explain the increased cardiovascular disease risk observed in these conditions. Arterial stiffness can be estimated by quantifying pulse pressure but is better described by distensibility and compliance coefficients, pulse wave velocity and wave reflection. The most common non-invasive methodologies used to quantify these estimates of arterial stiffness (e.g. ultrasonography and applanation tonometry) are also described. We then review and summarise the current data on the associations between diabetes, the metabolic syndrome and insulin resistance on the one hand and greater arterial stiffness on the other, and identify and discuss some unresolved issues such as differential stiffening of central vs peripheral arterial segments, the impact of sex, and the pathobiology of increased arterial stiffness in diabetes and the metabolic syndrome. Finally, some considerations with regard to treatment options are presented. At present the most powerful therapy available for reducing arterial stiffness is to vigorously treat hypertension using pharmacological agents. New pharmacological strategies to reduce arterial stiffness are likely to be especially relevant to individuals with diabetes.
Keyword Arterial stiffness
Cardiovascular disease
Diabetes
Insulin resistance
Metabolic syndrome
Pathophysiology
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: School of Public Health Publications
 
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