Effect of Moderate to Vigorous Physical Activity on All-Cause Mortality in Middle-aged and Older Australians

Gebel, Klaus, Ding, Ding, Chey, Tien, Stamatakis, Emmanuel, Brown, Wendy J and Bauman, Adrian E (2015) Effect of Moderate to Vigorous Physical Activity on All-Cause Mortality in Middle-aged and Older Australians. JAMA Internal Medicine, 175 6: 970-977. doi:10.1001/jamainternmed.2015.0541

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Author Gebel, Klaus
Ding, Ding
Chey, Tien
Stamatakis, Emmanuel
Brown, Wendy J
Bauman, Adrian E
Title Effect of Moderate to Vigorous Physical Activity on All-Cause Mortality in Middle-aged and Older Australians
Journal name JAMA Internal Medicine   Check publisher's open access policy
ISSN 2168-6106
2168-6114
Publication date 2015-06-01
Year available 2015
Sub-type Article (original research)
DOI 10.1001/jamainternmed.2015.0541
Open Access Status File (Publisher version)
Volume 175
Issue 6
Start page 970
End page 977
Total pages 8
Place of publication Chicago, United States
Publisher American Medical Association
Language eng
Formatted abstract
Importance Few studies have examined how different proportions of moderate and vigorous physical activity affect health outcomes.

Objective To examine whether the proportion of total moderate to vigorous activity (MVPA) that is achieved through vigorous activity is associated with all-cause mortality independently of the total amount of MVPA.

Design, Setting, and Participants We performed a prospective cohort study with activity data linked to all-cause mortality data from February 1, 2006, through June 15, 2014, in 204 542 adults aged 45 through 75 years from the 45 and Up population-based cohort study from New South Wales, Australia (mean [SD] follow-up, 6.52 [1.23] years). Associations between different contributions of vigorous activity to total MVPA and mortality were examined using Cox proportional hazards models, adjusted for total MVPA and sociodemographic and health covariates.

Exposures Different proportions of total MVPA as vigorous activity. Physical activity was measured with the Active Australia Survey.

Main Outcomes and Measures All-cause mortality during the follow-up period.

Results During 1 444 927 person-years of follow-up, 7435 deaths were registered. Compared with those who reported no MVPA (crude death rate, 8.34%), the adjusted hazard ratios for all-cause mortality were 0.66 (95% CI, 0.61-0.71; crude death rate, 4.81%), 0.53 (95% CI, 0.48-0.57; crude death rate, 3.17%), and 0.46 (95% CI, 0.43-0.49; crude death rate, 2.64%) for reporting 10 through 149, 150 through 299, and 300 min/wk or more of activity, respectively. Among those who reported any MVPA, the proportion of vigorous activity revealed an inverse dose-response relationship with all-cause mortality: compared with those reporting no vigorous activity (crude death rate, 3.84%) the fully adjusted hazard ratio was 0.91 (95% CI, 0.84-0.98; crude death rate, 2.35%) in those who reported some vigorous activity (but <30% of total activity) and 0.87 (95% CI, 0.81-0.93; crude death rate, 2.08%) among those who reported 30% or more of activity as vigorous. These associations were consistent in men and women, across categories of body mass index and volume of MVPA, and in those with and without existing cardiovascular disease or diabetes mellitus.

Conclusions and Relevance Among people reporting any activity, there was an inverse dose-response relationship between proportion of vigorous activity and mortality. Our findings suggest that vigorous activities should be endorsed in clinical and public health activity guidelines to maximize the population benefits of physical activity.
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Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Human Movement and Nutrition Sciences Publications
 
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Created: Wed, 13 May 2015, 20:00:50 EST by Sandrine Ducrot on behalf of School of Human Movement and Nutrition Sciences