Bronchiolitis obliterans organising pneumonia: a clinical and radiological review

Boots, R. J., McEvoy, J. D., Mowat, P. and Le Fevre, I. (1995) Bronchiolitis obliterans organising pneumonia: a clinical and radiological review. Australia and New Zealand Journal of Medicine, 25 2: 140-145.

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Name Description MIMEType Size Downloads
Author Boots, R. J.
McEvoy, J. D.
Mowat, P.
Le Fevre, I.
Title Bronchiolitis obliterans organising pneumonia: a clinical and radiological review
Journal name Australia and New Zealand Journal of Medicine   Check publisher's open access policy
ISSN 1445-1433
Publication date 1995-01-01
Sub-type Article (original research)
Volume 25
Issue 2
Start page 140
End page 145
Total pages 6
Place of publication Richmond, VIC Australia
Publisher Wiley-Blackwell Publishing Asia
Language eng
Formatted abstract
Background: The clinical presentation, course, and radiological spectrum of bronchiolitis obliterans organising pneumonia (BOOP) is still being characterised to aid differentiation from other causes of organising pneumonia.

Aims: To define the clinical presentation, response to therapy, and radiological spectrum of BOOP.

Methods: Fifteen cases of BOOP were retrospectively reviewed. The clinical presenting features, treatment and outcome of each patient were determined. Three independent readers and chest X-rays (CXRs) were blinded. CXRs were scored by a semi-quantitative method. Modal scores were calculated for type and profusion of opacification of each CXR.

Results: The mean age of presentation was 64 years and the median duration of follow-up was 12.5 months. Thirteen patients received corticosteroid therapy. Outcome was varied. One patient had progressive loss of lung function, five had persisting symptoms with stable abnormal lung function, and nine were asymptomatic with near normal lung function. Five patients had a disease relapse. Symptom length prior to presentation, duration and intensity of treatment were not
associated with outcome 0, = 0.23-0.9). Radiological opacities were alveolar in 7370, large localised infiltrates in 13%, nodular in 20% and mobile in 33% of CXR series. There was no relationship between overall profusion, type of CXR opacities and patient outcome, treatment duration or treatment intensity @ = 0.42-1.0).

Conclusions: The clinical spectrum of BOOP includes mild subacute, chronic progressive, and acute life threatening illness. Prognosis and response to treatment is variable. The diversity of radiological findings and clinical presentations should prompt consideration of the diagnosis in patients with undiagnosed respiratory tract symptoms and persisting or varying radiological abnormalities.
Keyword Bronchiolitis Obliterans
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 18 times in Thomson Reuters Web of Science Article | Citations
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Created: Tue, 12 May 2015, 06:32:38 EST by Robert Boots on behalf of Anaesthesiology and Critical Care - RBWH