High resolution particle characterization to expedite development and regulatory acceptance of nanomedicines

Kozak, Darby, Broom, Murray and Vogel, Robert (2015) High resolution particle characterization to expedite development and regulatory acceptance of nanomedicines. Current Drug Delivery, 12 1: 115-120. doi:10.2174/1567201811666140922110647


Author Kozak, Darby
Broom, Murray
Vogel, Robert
Title High resolution particle characterization to expedite development and regulatory acceptance of nanomedicines
Journal name Current Drug Delivery   Check publisher's open access policy
ISSN 1567-2018
1875-5704
Publication date 2015-01-01
Year available 2015
Sub-type Article (original research)
DOI 10.2174/1567201811666140922110647
Open Access Status Not yet assessed
Volume 12
Issue 1
Start page 115
End page 120
Total pages 6
Place of publication Bussum, Netherlands
Publisher Bentham Science Publishers
Collection year 2016
Language eng
Abstract The pharmaceutical industry as well as European and US governing agencies have indicated the need for more accurate, high resolution, characterization of complex drug materials, nanomedicines, to facilitate their development and eventual approval. In particular, accurately measuring the size, zeta-potential, and concentration of nanomedicines is desired. Herein we demonstrate the comprehensive and high resolution analysis capabilities of tunable resistive pulse sensing (TRPS) on the most widely approved nanomedicines to-date, liposomal particles. The number-based size distribution, concentration and volume fraction of liposomes formed by extrusion through a 100 nm or 200 nm Nucleopore filter membrane are shown as well as how freeze-thaw aggregation changes individual liposomes and the overall size distribution. In addition, the simultaneous size and zeta-potential analysis capabilities of TRPS is used to characterize the homogeneity and difference between liposomes made with and without the addition of PEGylated phospholipids.
Keyword Coulter counter
Particle characterization
Pore sensor
Trps
qNano
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: School of Mathematics and Physics
Official 2016 Collection
 
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