Diagnostic accuracy of Narrow Band Imaging for the detection of oral potentially malignant disorders

Vu, A. N., Matias, M. A. T. and Farah, C. S. (2015) Diagnostic accuracy of Narrow Band Imaging for the detection of oral potentially malignant disorders. Oral Diseases, 21 4: 519-529. doi:10.1111/odi.12315


Author Vu, A. N.
Matias, M. A. T.
Farah, C. S.
Title Diagnostic accuracy of Narrow Band Imaging for the detection of oral potentially malignant disorders
Journal name Oral Diseases   Check publisher's open access policy
ISSN 1601-0825
1354-523X
Publication date 2015-05-01
Year available 2015
Sub-type Article (original research)
DOI 10.1111/odi.12315
Open Access Status DOI
Volume 21
Issue 4
Start page 519
End page 529
Total pages 11
Place of publication Hoboken, NJ, United States
Publisher Wiley-Blackwell Publishing
Language eng
Subject 2733 Otorhinolaryngology
3500 Dentistry
Abstract Objective: To determine the clinical diagnostic accuracy of Narrow Band Imaging for the detection of oral potentially malignant disorders in a prospective series of patients. Materials and Methods: New and existing patients referred to an oral medicine and pathology specialist clinic for assessment of at least one white, red or red-white oral mucosal lesion underwent conventional oral examination, followed by examination with the white light mode and then narrow band imaging mode of a Narrow Band Imaging system. The clinical presentation, microvascular architecture and relevant histopathology of all lesions were recorded. Results: A total of 272 lesions from 95 patients were observed. The sensitivity, specificity, positive predictive value, negative predictive value and accuracy for the detection of oral potentially malignant disorders or worse by Narrow Band Imaging were 100%, 74.63%, 92.38%, 100% and 93.77%, respectively, when compared with conventional oral examination. Narrow Band Imaging aided the detection of 24 lesions undetected by conventional oral examination and 13 lesions undetected by white light endoscopy. Conclusion: Narrow Band Imaging demonstrates great utility as a visualisation adjunct for detecting and monitoring oral potentially malignant diseases, particularly lesions not identified by conventional oral examination or white light examination alone.
Formatted abstract
Objective: To determine the clinical diagnostic accuracy of Narrow Band Imaging™ for the detection of oral potentially malignant disorders in a prospective series of patients.

Materials and Methods: New and existing patients referred to an oral medicine and pathology specialist clinic for assessment of at least one white, red or red-white oral mucosal lesion underwent conventional oral examination, followed by examination with the white light mode and then narrow band imaging mode of a Narrow Band Imaging™ system. The clinical presentation, microvascular architecture and relevant histopathology of all lesions were recorded.

Results: A total of 272 lesions from 95 patients were observed. The sensitivity, specificity, positive predictive value, negative predictive value and accuracy for the detection of oral potentially malignant disorders or worse by Narrow Band Imaging™ were 100%, 74.63%, 92.38%, 100% and 93.77%, respectively, when compared with conventional oral examination. Narrow Band Imaging™ aided the detection of 24 lesions undetected by conventional oral examination and 13 lesions undetected by white light endoscopy.

Conclusion: Narrow Band Imaging™ demonstrates great utility as a visualisation adjunct for detecting and monitoring oral potentially malignant diseases, particularly lesions not identified by conventional oral examination or white light examination alone.
Keyword Detection
Narrow band imaging
Oral potentially malignant lesions
Sensitivity
Specificity
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
Official 2016 Collection
 
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