The regulation of oxytocin receptor gene expression during adipogenesis

Yi K.J., So K.H., Hata Y., Suzuki Y., Kato D., Watanabe K., Aso H., Kasahara Y., Nishimori K., Chen, Chen, Katoh K. and Roh S.G. (2015) The regulation of oxytocin receptor gene expression during adipogenesis. Journal of Neuroendocrinology, 27 5: 335-342. doi:10.1111/jne.12268

Author Yi K.J.
So K.H.
Hata Y.
Suzuki Y.
Kato D.
Watanabe K.
Aso H.
Kasahara Y.
Nishimori K.
Chen, Chen
Katoh K.
Roh S.G.
Title The regulation of oxytocin receptor gene expression during adipogenesis
Journal name Journal of Neuroendocrinology   Check publisher's open access policy
ISSN 1365-2826
Publication date 2015-05-01
Year available 2015
Sub-type Article (original research)
DOI 10.1111/jne.12268
Open Access Status Not Open Access
Volume 27
Issue 5
Start page 335
End page 342
Total pages 8
Place of publication Chichester, United Kingdom
Publisher Wiley-Blackwell Publishing Ltd
Language eng
Abstract Although it has been reported that oxytocin stimulates lipolysis in adipocytes, changes in the expression of oxytocin receptor (OTR) mRNA in adipogenesis are still unknown. The present study aimed to investigate the expression of OTR mRNA during adipocyte differentiation and fat accumulation in adipocytes. OTR mRNA was highly expressed in adipocytes prepared from mouse adipose tissues compared to stromal-vascular cells. OTR mRNA expression was increased during the adipocyte differentiation of 3T3-L1 cells. OTR expression levels were higher in subcutaneous and epididymal adipose tissues of 14-week-old male mice compared to 7-week-old male mice. Levels of OTR mRNA expression were higher in adipose tissues at four different sites of mice fed a high-fat diet than in those of mice fed a normal diet. The OTR expression level was also increased by refeeding for 4 h after fasting for 16 h. Oxytocin significantly induced lipolysis in 3T3-L1 adipocytes. In conclusion, a new regulatory mechanism is demonstrated for oxytocin to control the differentiation and fat accumulation in adipocytes via activation of OTR as a part of the hypothalamic-pituitary-adipose axis.
Keyword Oxytocin
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Biomedical Sciences Publications
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