Cavin family proteins and the assembly of caveolae

Kovtun, Oleksiy, Tillu, Vikas A., Ariotti, Nicholas, Parton, Robert G. and Collins, Brett M. (2015) Cavin family proteins and the assembly of caveolae. Journal of Cell Science, 128 7: 1269-1278. doi:10.1242/jcs.167866


Author Kovtun, Oleksiy
Tillu, Vikas A.
Ariotti, Nicholas
Parton, Robert G.
Collins, Brett M.
Title Cavin family proteins and the assembly of caveolae
Journal name Journal of Cell Science   Check publisher's open access policy
ISSN 0021-9533
1477-9137
Publication date 2015-04-01
Year available 2015
Sub-type Editorial
DOI 10.1242/jcs.167866
Open Access Status DOI
Volume 128
Issue 7
Start page 1269
End page 1278
Total pages 10
Place of publication Cambridge, United Kingdom
Publisher The Company of Biologists
Language eng
Abstract Caveolae are an abundant feature of the plasma membrane in many cells. Until recently, they were generally considered to be membrane invaginations whose formation primarily driven by integral membrane proteins called caveolins. However, the past decade has seen the emergence of the cavin family of peripheral membrane proteins as essential coat components and regulators of caveola biogenesis. In this Commentary, we summarise recent data on the role of cavins in caveola formation, highlighting structural studies that provide new insights into cavin coat assembly. In mammals, there are four cavin family members that associate through homo- and hetero-oligomerisation to form distinct subcomplexes on caveolae, which can be released into the cell in response to stimuli. Studies from several labs have provided a better understanding of cavin stoichiometry and the molecular basis for their oligomerisation, as well as identifying interactions with membrane phospholipids that may be important for caveola function. We propose a model in which coincident, low-affinity electrostatically controlled protein–protein and protein–lipid interactions allow the formation of caveolae, generating a meta-stable structure that can respond to plasma membrane stress by release of cavins.
Keyword Caveolae
Caveolin
Cavin
Coiled coil
Electron microscopy
X-ray crystallography
Deprivation-Response-Gene
Transcript Release Factor
Plasma-Membrane
Binding protein
Polymerase-I
Phosphatidylinositol 4,5-Bisphosphate
Serum starvation
Lipid bodies
Cholesterol
Ptrf
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

 
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