Heterogeneity of genetic architecture of body size traits in a free-living population

Berenos, Camillo, Ellis, Philip A., Pilkington, Jill G., Lee, S. Hong, Gratten, Jake and Pemberton, Josephine M. (2015) Heterogeneity of genetic architecture of body size traits in a free-living population. Molecular Ecology, 24 8: 1810-1830. doi:10.1111/mec.13146

Author Berenos, Camillo
Ellis, Philip A.
Pilkington, Jill G.
Lee, S. Hong
Gratten, Jake
Pemberton, Josephine M.
Title Heterogeneity of genetic architecture of body size traits in a free-living population
Journal name Molecular Ecology   Check publisher's open access policy
ISSN 1365-294X
Publication date 2015-04-01
Year available 2015
Sub-type Article (original research)
DOI 10.1111/mec.13146
Open Access Status Not yet assessed
Volume 24
Issue 8
Start page 1810
End page 1830
Total pages 21
Place of publication West Sussex, United Kingdom
Publisher Wiley-Blackwell Publishing
Language eng
Abstract Knowledge of the underlying genetic architecture of quantitative traits could aid in understanding how they evolve. In wild populations, it is still largely unknown whether complex traits are polygenic or influenced by few loci with major effect, due to often small sample sizes and low resolution of marker panels. Here, we examine the genetic architecture of five adult body size traits in a free-living population of Soay sheep on St Kilda using 37 037 polymorphic SNPs. Two traits (jaw and weight) show classical signs of a polygenic trait: the proportion of variance explained by a chromosome was proportional to its length, multiple chromosomes and genomic regions explained significant amounts of phenotypic variance, but no SNPs were associated with trait variance when using GWAS. In comparison, genetic variance for leg length traits (foreleg, hindleg and metacarpal) was disproportionately explained by two SNPs on chromosomes 16 (s23172.1) and 19 (s74894.1), which each explained >10% of the additive genetic variance. After controlling for environmental differences, females heterozygous for s74894.1 produced more lambs and recruits during their lifetime than females homozygous for the common allele conferring long legs. We also demonstrate that alleles conferring shorter legs have likely entered the population through a historic admixture event with the Dunface sheep. In summary, we show that different proxies for body size can have very different genetic architecture and that dense SNP helps in understanding both the mode of selection and the evolutionary history at loci underlying quantitative traits in natural populations.
Keyword Admixture
Body size
Genetic architecture
Genome partitioning
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2016 Collection
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Citation counts: TR Web of Science Citation Count  Cited 13 times in Thomson Reuters Web of Science Article | Citations
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